Adverse events (grade ≥ 3) observed in 5% or more of patients treated with either zosuquidar or placebo
| . | Zosuquidar (n = 219), % . | Placebo (n = 220), % . |
|---|---|---|
| Hematologic | ||
| Hemoglobin | 73 | 69 |
| Leukocytes | 93 | 96 |
| Neutrophils | 91 | 92 |
| Platelets | 96 | 96 |
| Transfusion: platelets | 9 | 11 |
| Transfusion: PRBCs | 8 | 8 |
| Nonhematologic | ||
| Supraventricular arrhythmias | 7 | 4 |
| Hypotension | 7 | 4 |
| Fatigue | 17 | 10 |
| Anorexia | 13 | 9 |
| Nausea | 8 | 6 |
| Stomatitis | 9 | 5 |
| Diarrhea without prior colostomy | 7 | 6 |
| Epistaxis | 6 | 6 |
| Petechiae | 3 | 6 |
| Bilirubin | 16 | 14 |
| Febrile neutropenia | 42 | 38 |
| Infection with grade 3 or 4 neutropenia | 54 | 55 |
| Ataxia | 8 | 1 |
| Confusion | 8 | 1 |
| Hallucinations | 11 | 5 |
| Dyspnea | 10 | 10 |
| Hypoxia | 7 | 6 |
| Pneumonitis/pulmonary infiltrates | 6 | 5 |
| . | Zosuquidar (n = 219), % . | Placebo (n = 220), % . |
|---|---|---|
| Hematologic | ||
| Hemoglobin | 73 | 69 |
| Leukocytes | 93 | 96 |
| Neutrophils | 91 | 92 |
| Platelets | 96 | 96 |
| Transfusion: platelets | 9 | 11 |
| Transfusion: PRBCs | 8 | 8 |
| Nonhematologic | ||
| Supraventricular arrhythmias | 7 | 4 |
| Hypotension | 7 | 4 |
| Fatigue | 17 | 10 |
| Anorexia | 13 | 9 |
| Nausea | 8 | 6 |
| Stomatitis | 9 | 5 |
| Diarrhea without prior colostomy | 7 | 6 |
| Epistaxis | 6 | 6 |
| Petechiae | 3 | 6 |
| Bilirubin | 16 | 14 |
| Febrile neutropenia | 42 | 38 |
| Infection with grade 3 or 4 neutropenia | 54 | 55 |
| Ataxia | 8 | 1 |
| Confusion | 8 | 1 |
| Hallucinations | 11 | 5 |
| Dyspnea | 10 | 10 |
| Hypoxia | 7 | 6 |
| Pneumonitis/pulmonary infiltrates | 6 | 5 |
PRBCs indicates packed red blood cells.