Up-regulated genes shared by zebrafish, murine, and human HSCs
| Gene symbol . | Fold change . | EntrezGene ID . | Description . | ||||
|---|---|---|---|---|---|---|---|
| zSPs . | mHSCs . | hHSCs . | Zebrafish . | Mouse . | Human . | ||
| ahnak | 2.9 | 1.7 | 1.7 | 336775 | 66395 | 79026 | AHNAK nucleoprotein (desmoyokin) |
| anxa5 | 4.1 | 3.5 | 1.2 | 337132 | 11747 | 308 | Annexin A5 |
| apoe | 6.8 | 37.5 | 1.3 | 30314 | 11816 | 348 | Apolipoprotein E |
| arih2 | 3.6 | 1.8 | 1.3 | 406417 | 23807 | 10425 | Ariadne homolog 2 (Drosophila) |
| arl4a | 7.7 | 2.2 | 1.2 | 338267 | 11861 | 10124 | ADP-ribosylation factor-like 4A |
| arrdc3 | 7.5 | 1.6 | 1.6 | 566685 | 105171 | 57561 | Arrestin domain containing 3 |
| clk4 | 6.4 | 1.9 | 1.4 | 321857 | 12750 | 57396 | CDC-like kinase 4 |
| ctdspl | 11.0 | 1.5 | 1.4 | 334523 | 69274 | 10217 | Carboxy-terminal domain (RNA polymerase II, polypeptide A) small phosphatase-like |
| ctsf | 5.5 | 6.0 | 1.7 | 321249 | 56464 | 8722 | Cathepsin F |
| dach1 | 3.0 | 3.3 | 1.8 | 192123 | 13134 | 1602 | Dachshund 1 (Drosophila) |
| dst | 12.4 | 3.0 | 1.7 | 324678 | 13518 | 667 | Dystonin |
| egr1 | 3.9 | 2.4 | 1.4 | 30498 | 13653 | 1958 | Early growth response 1 |
| etv5 | 13.7 | 2.1 | 1.8 | 30452 | 104156 | 2119 | ets variant gene 5 |
| f11r | 19.5 | 4.8 | 1.3 | 323696 | 16456 | 50848 | F11 receptor |
| fhl1 | 7.7 | 10.8 | 1.5 | 387528 | 14199 | 2273 | Four and a half LIM domains 1 |
| fosl2 | 5.7 | 2.2 | 2.3 | 335267 | 14284 | 2355 | fos-like antigen 2 |
| fry | 3.4 | 2.5 | 1.5 | 558173 | 320365 | 10129 | Furry homolog (Drosophila) |
| gata2 | 4.1 | 7.4 | 1.4 | 30480 | 14461 | 2624 | GATA-binding protein 2 |
| gnai1 | 2.8 | 2.1 | 1.2 | 393946 | 14677 | 2770 | Guanine nucleotide-binding protein (G protein), α-inhibiting activity polypeptide 1 |
| id1 | 11.2 | 2.0 | 1.5 | 30493 | 15901 | 3397 | Inhibitor of DNA binding 1 |
| kif1b | 4.0 | 3.7 | 1.3 | 322825 | 16561 | 23095 | Kinesin family member 1B |
| krt18 | 103.4 | 5.7 | 1.5 | 352912 | 16668 | 3875 | Keratin 18 |
| lysmd3 | 4.5 | 1.6 | 1.4 | 415194 | 80289 | 116068 | LysM, putative peptidoglycan binding, domain containing 3 |
| maff | 9.8 | 4.4 | 1.6 | 393307 | 17133 | 23764 | v-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian) |
| mcl1 | 5.6 | 2.3 | 1.5 | 373102 | 17210 | 4170 | Myeloid cell leukemia sequence 1 |
| meis1 | 4.8 | 2.9 | 1.3 | 170446 | 17268 | 4211 | Myeloid ecotropic viral integration 1 |
| midn | 5.0 | 1.7 | 1.5 | 323713 | 59090 | 90007 | Midnolin |
| per2 | 4.3 | 1.8 | 1.4 | 140633 | 18627 | 8864 | Period homolog 2 (Drosophila) |
| perp | 10.3 | 1.6 | 2.0 | 494479 | 64058 | 64065 | PERP, TP53 apoptosis effector |
| phlda2 | 23.3 | 4.6 | 2.6 | 553622 | 22113 | 7262 | Pleckstrin homology-like domain, family A, member 2 |
| prkag2 | 7.4 | 1.7 | 1.2 | 570761 | 108099 | 51422 | Protein kinase, AMP-activated, γ2 noncatalytic subunit |
| rassf8 | 3.4 | 2.0 | 1.9 | 393334 | 71323 | 11228 | Ras association (RalGDS/AF-6) domain family 8 |
| rras | 4.8 | 3.7 | 1.4 | 449660 | 20130 | 6237 | Harvey rat sarcoma oncogene, subgroup R |
| rrbp1 | 3.3 | 1.7 | 1.4 | 321219 | 81910 | 6238 | Ribosome-binding protein 1 |
| tfpi | 3.9 | 2.8 | 1.5 | 796294 | 21788 | 7035 | Tissue factor pathway inhibitor |
| timp2 | 7.1 | 4.3 | 1.3 | 406650 | 21858 | 7077 | Tissue inhibitor of metalloproteinase 2 |
| tiparp | 3.4 | 2.0 | 1.4 | 323584 | 99929 | 25976 | TCDD-inducible poly(ADP-ribose) polymerase |
| uap1 | 8.6 | 2.0 | 1.2 | 322513 | 227620 | 6675 | UDP-N-acetylglucosamine pyrophosphorylase 1 |
| zbtb16 | 5.8 | 1.7 | 2.4 | 325688 | 235320 | 7704 | Zinc finger and BTB domain containing 16 |
| zmym6 | 6.2 | 1.7 | 1.4 | 553317 | 100177 | 9204 | Zinc finger, MYM-type 6 |
| Gene symbol . | Fold change . | EntrezGene ID . | Description . | ||||
|---|---|---|---|---|---|---|---|
| zSPs . | mHSCs . | hHSCs . | Zebrafish . | Mouse . | Human . | ||
| ahnak | 2.9 | 1.7 | 1.7 | 336775 | 66395 | 79026 | AHNAK nucleoprotein (desmoyokin) |
| anxa5 | 4.1 | 3.5 | 1.2 | 337132 | 11747 | 308 | Annexin A5 |
| apoe | 6.8 | 37.5 | 1.3 | 30314 | 11816 | 348 | Apolipoprotein E |
| arih2 | 3.6 | 1.8 | 1.3 | 406417 | 23807 | 10425 | Ariadne homolog 2 (Drosophila) |
| arl4a | 7.7 | 2.2 | 1.2 | 338267 | 11861 | 10124 | ADP-ribosylation factor-like 4A |
| arrdc3 | 7.5 | 1.6 | 1.6 | 566685 | 105171 | 57561 | Arrestin domain containing 3 |
| clk4 | 6.4 | 1.9 | 1.4 | 321857 | 12750 | 57396 | CDC-like kinase 4 |
| ctdspl | 11.0 | 1.5 | 1.4 | 334523 | 69274 | 10217 | Carboxy-terminal domain (RNA polymerase II, polypeptide A) small phosphatase-like |
| ctsf | 5.5 | 6.0 | 1.7 | 321249 | 56464 | 8722 | Cathepsin F |
| dach1 | 3.0 | 3.3 | 1.8 | 192123 | 13134 | 1602 | Dachshund 1 (Drosophila) |
| dst | 12.4 | 3.0 | 1.7 | 324678 | 13518 | 667 | Dystonin |
| egr1 | 3.9 | 2.4 | 1.4 | 30498 | 13653 | 1958 | Early growth response 1 |
| etv5 | 13.7 | 2.1 | 1.8 | 30452 | 104156 | 2119 | ets variant gene 5 |
| f11r | 19.5 | 4.8 | 1.3 | 323696 | 16456 | 50848 | F11 receptor |
| fhl1 | 7.7 | 10.8 | 1.5 | 387528 | 14199 | 2273 | Four and a half LIM domains 1 |
| fosl2 | 5.7 | 2.2 | 2.3 | 335267 | 14284 | 2355 | fos-like antigen 2 |
| fry | 3.4 | 2.5 | 1.5 | 558173 | 320365 | 10129 | Furry homolog (Drosophila) |
| gata2 | 4.1 | 7.4 | 1.4 | 30480 | 14461 | 2624 | GATA-binding protein 2 |
| gnai1 | 2.8 | 2.1 | 1.2 | 393946 | 14677 | 2770 | Guanine nucleotide-binding protein (G protein), α-inhibiting activity polypeptide 1 |
| id1 | 11.2 | 2.0 | 1.5 | 30493 | 15901 | 3397 | Inhibitor of DNA binding 1 |
| kif1b | 4.0 | 3.7 | 1.3 | 322825 | 16561 | 23095 | Kinesin family member 1B |
| krt18 | 103.4 | 5.7 | 1.5 | 352912 | 16668 | 3875 | Keratin 18 |
| lysmd3 | 4.5 | 1.6 | 1.4 | 415194 | 80289 | 116068 | LysM, putative peptidoglycan binding, domain containing 3 |
| maff | 9.8 | 4.4 | 1.6 | 393307 | 17133 | 23764 | v-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian) |
| mcl1 | 5.6 | 2.3 | 1.5 | 373102 | 17210 | 4170 | Myeloid cell leukemia sequence 1 |
| meis1 | 4.8 | 2.9 | 1.3 | 170446 | 17268 | 4211 | Myeloid ecotropic viral integration 1 |
| midn | 5.0 | 1.7 | 1.5 | 323713 | 59090 | 90007 | Midnolin |
| per2 | 4.3 | 1.8 | 1.4 | 140633 | 18627 | 8864 | Period homolog 2 (Drosophila) |
| perp | 10.3 | 1.6 | 2.0 | 494479 | 64058 | 64065 | PERP, TP53 apoptosis effector |
| phlda2 | 23.3 | 4.6 | 2.6 | 553622 | 22113 | 7262 | Pleckstrin homology-like domain, family A, member 2 |
| prkag2 | 7.4 | 1.7 | 1.2 | 570761 | 108099 | 51422 | Protein kinase, AMP-activated, γ2 noncatalytic subunit |
| rassf8 | 3.4 | 2.0 | 1.9 | 393334 | 71323 | 11228 | Ras association (RalGDS/AF-6) domain family 8 |
| rras | 4.8 | 3.7 | 1.4 | 449660 | 20130 | 6237 | Harvey rat sarcoma oncogene, subgroup R |
| rrbp1 | 3.3 | 1.7 | 1.4 | 321219 | 81910 | 6238 | Ribosome-binding protein 1 |
| tfpi | 3.9 | 2.8 | 1.5 | 796294 | 21788 | 7035 | Tissue factor pathway inhibitor |
| timp2 | 7.1 | 4.3 | 1.3 | 406650 | 21858 | 7077 | Tissue inhibitor of metalloproteinase 2 |
| tiparp | 3.4 | 2.0 | 1.4 | 323584 | 99929 | 25976 | TCDD-inducible poly(ADP-ribose) polymerase |
| uap1 | 8.6 | 2.0 | 1.2 | 322513 | 227620 | 6675 | UDP-N-acetylglucosamine pyrophosphorylase 1 |
| zbtb16 | 5.8 | 1.7 | 2.4 | 325688 | 235320 | 7704 | Zinc finger and BTB domain containing 16 |
| zmym6 | 6.2 | 1.7 | 1.4 | 553317 | 100177 | 9204 | Zinc finger, MYM-type 6 |
ADP indicates adenosine diphosphate; CDC, cell division cycle; PERP, p53 apoptosis effector related to peripheral myelin protein 22; AMP, adenosine monophosphate; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin; and UDP, uridine diphosphate.