Table 2

Enriched GO terms for down-regulated genes of zSPs

GO termGO IDOntologyObserved genesTotal genesP
Ribonucleoprotein complex GO:0030529 CC 47 282 < .001 
Nonmembrane-bound organelle GO:0043228 CC 42 276 < .001 
DNA-directed DNA polymerase activity GO:0003887 MF < .001 
RNA binding GO:0003723 MF 22 122 .002 
Nucleotidyltransferase activity GO:0016779 MF 39 .008 
Exonuclease activity GO:0004527 MF 19 .026 
Translation GO:0006412 BP 36 154 < .001 
DNA metabolic process GO:0006259 BP 23 129 < .001 
RNA processing GO:0006396 BP 12 61 .007 
DNA packaging GO:0006323 BP 36 .012 
Chromosome organization and biogenesis GO:0051276 BP 45 .016 
DNA replication GO:0006260 BP 32 .02 
Response to stress GO:0006950 BP 16 105 .022 
DNA repair GO:0006281 BP 42 .029 
GO termGO IDOntologyObserved genesTotal genesP
Ribonucleoprotein complex GO:0030529 CC 47 282 < .001 
Nonmembrane-bound organelle GO:0043228 CC 42 276 < .001 
DNA-directed DNA polymerase activity GO:0003887 MF < .001 
RNA binding GO:0003723 MF 22 122 .002 
Nucleotidyltransferase activity GO:0016779 MF 39 .008 
Exonuclease activity GO:0004527 MF 19 .026 
Translation GO:0006412 BP 36 154 < .001 
DNA metabolic process GO:0006259 BP 23 129 < .001 
RNA processing GO:0006396 BP 12 61 .007 
DNA packaging GO:0006323 BP 36 .012 
Chromosome organization and biogenesis GO:0051276 BP 45 .016 
DNA replication GO:0006260 BP 32 .02 
Response to stress GO:0006950 BP 16 105 .022 
DNA repair GO:0006281 BP 42 .029 

These are GO terms that are significantly overrepresented in the down-regulated genes of zSPs. Shown in this table is a subset of 14 representative significant GO terms.

CC indicates cellular component; MF, molecular function; and BP, biological process.

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