Rai classification and Binet staging systems for CLL
| System . | Clinical features . | Median survival, y . |
|---|---|---|
| Rai stage (simplified 3-stage) | ||
| 0 (low risk) | Lymphocytosis in blood and marrow only | > 10 |
| I and II (intermediate risk) | Lymphadenopathy, splenomegaly +/− hepatomegaly | 7 |
| III and IV (high risk) | Anemia, thrombocytopenia | 0.75-4 |
| Binet group | ||
| A | Fewer than 3 areas of lymphadenopathy; no anemia or thrombocytopenia | 12 |
| B | More than 3 involved node areas; no anemia or thrombocytopenia | 7 |
| C | Hemoglobin < 100 g/L platelets < 100 × 10 g/L | 2-4 |
| System . | Clinical features . | Median survival, y . |
|---|---|---|
| Rai stage (simplified 3-stage) | ||
| 0 (low risk) | Lymphocytosis in blood and marrow only | > 10 |
| I and II (intermediate risk) | Lymphadenopathy, splenomegaly +/− hepatomegaly | 7 |
| III and IV (high risk) | Anemia, thrombocytopenia | 0.75-4 |
| Binet group | ||
| A | Fewer than 3 areas of lymphadenopathy; no anemia or thrombocytopenia | 12 |
| B | More than 3 involved node areas; no anemia or thrombocytopenia | 7 |
| C | Hemoglobin < 100 g/L platelets < 100 × 10 g/L | 2-4 |