IFN-α–regulated macrophage genes
| Gene symbol . | Gene title . | FC, IFN-α/C* . |
|---|---|---|
| TNFAIP6 | Tumor necrosis factor, alpha-induced protein 6 | 404.21 |
| CXCL10 | Chemokine (C-X-C motif) ligand 10 | 390.45 |
| CCL20 | Chemokine (C-C motif) ligand 20 | 253.64 |
| IFIT2 | Interferon-induced protein with tetratricopeptide repeats 2 | 244.85 |
| RSAD2 | Radical S-adenosyl methionine domain containing 2 | 134.3 |
| INDO | Indoleamine-pyrrole 2,3 dioxygenase | 84.39 |
| ISG20 | Interferon stimulated exonuclease gene 20 kDa | 78.24 |
| CXCL11 | Chemokine (C-X-C motif) ligand 11 | 71 |
| IFIT1 | Interferon-induced protein with tetratricopeptide repeats 1 | 70.45 |
| CCL5 | Chemokine (C-C motif) ligand 5 | 70.2 |
| LOC730249 | Similar to immune-responsive protein 1 | 60.63 |
| IFIT3 | Interferon-induced protein with tetratricopeptide repeats 3 | 59.49 |
| TNFSF10 | Tumor necrosis factor (ligand) superfamily, member 10 | 58.59 |
| PTX3 | Pentraxin-related gene, rapidly induced by IL-1 beta | 56.11 |
| LAMP3 | Lysosomal-associated membrane protein 3 | 52.54 |
| TNIP3 | TNFAIP3 interacting protein 3 | 49.16 |
| IL7R | Interleukin-7 receptor | 48.11 |
| GCH1 | GTP cyclohydrolase 1 (dopa-responsive dystonia) | 44.27 |
| IL6 | Interleukin-6 (interferon, beta 2) | 43.62 |
| ISG15 | ISG15 ubiquitin-like modifier | 41.89 |
| EBI3 | Epstein-Barr virus induced gene 3 | 41.76 |
| CXCL1 | Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 34.96 |
| LRRC50 | Leucine rich repeat containing 50 | 34.81 |
| LOC440896 | Hypothetical gene supported by AK127288; AY343901 | 34.79 |
| OASL | 2′-5′-oligoadenylate synthetase-like | 33.49 |
| SOCS3 | Suppressor of cytokine signaling 3 | 32.8 |
| GBP1 | Guanylate binding protein 1, interferon-inducible, 67 kDa | 30.39 |
| IL12B | Interleukin 12B (natural killer cell stimulatory factor 2, p40) | 29.32 |
| CCL4 | Chemokine (C-C motif) ligand 4 | 27.97 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 26.81 |
| LOC129607 | Hypothetical protein LOC129607 | 26.46 |
| CCL8 | Chemokine (C-C motif) ligand 8 | 24.34 |
| IL8 | Interleukin 8 | 24.04 |
| ITGB8 | Integrin, beta 8 | 23.94 |
| CCR7 | Chemokine (C-C motif) receptor 7 | 23.68 |
| SOD2 | Superoxide dismutase 2, mitochondrial | 20.98 |
| ELOVL7 | ELOVL family member 7, elongation of long chain fatty acids (yeast) | 20.84 |
| MCOLN2 | Mucolipin 2 | 19.52 |
| SLAMF1 | Signaling lymphocytic activation molecule family member 1 | 17.26 |
| EGR1 | Early growth response 1 | 0.04 |
| Gene symbol . | Gene title . | FC, IFN-α/C* . |
|---|---|---|
| TNFAIP6 | Tumor necrosis factor, alpha-induced protein 6 | 404.21 |
| CXCL10 | Chemokine (C-X-C motif) ligand 10 | 390.45 |
| CCL20 | Chemokine (C-C motif) ligand 20 | 253.64 |
| IFIT2 | Interferon-induced protein with tetratricopeptide repeats 2 | 244.85 |
| RSAD2 | Radical S-adenosyl methionine domain containing 2 | 134.3 |
| INDO | Indoleamine-pyrrole 2,3 dioxygenase | 84.39 |
| ISG20 | Interferon stimulated exonuclease gene 20 kDa | 78.24 |
| CXCL11 | Chemokine (C-X-C motif) ligand 11 | 71 |
| IFIT1 | Interferon-induced protein with tetratricopeptide repeats 1 | 70.45 |
| CCL5 | Chemokine (C-C motif) ligand 5 | 70.2 |
| LOC730249 | Similar to immune-responsive protein 1 | 60.63 |
| IFIT3 | Interferon-induced protein with tetratricopeptide repeats 3 | 59.49 |
| TNFSF10 | Tumor necrosis factor (ligand) superfamily, member 10 | 58.59 |
| PTX3 | Pentraxin-related gene, rapidly induced by IL-1 beta | 56.11 |
| LAMP3 | Lysosomal-associated membrane protein 3 | 52.54 |
| TNIP3 | TNFAIP3 interacting protein 3 | 49.16 |
| IL7R | Interleukin-7 receptor | 48.11 |
| GCH1 | GTP cyclohydrolase 1 (dopa-responsive dystonia) | 44.27 |
| IL6 | Interleukin-6 (interferon, beta 2) | 43.62 |
| ISG15 | ISG15 ubiquitin-like modifier | 41.89 |
| EBI3 | Epstein-Barr virus induced gene 3 | 41.76 |
| CXCL1 | Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 34.96 |
| LRRC50 | Leucine rich repeat containing 50 | 34.81 |
| LOC440896 | Hypothetical gene supported by AK127288; AY343901 | 34.79 |
| OASL | 2′-5′-oligoadenylate synthetase-like | 33.49 |
| SOCS3 | Suppressor of cytokine signaling 3 | 32.8 |
| GBP1 | Guanylate binding protein 1, interferon-inducible, 67 kDa | 30.39 |
| IL12B | Interleukin 12B (natural killer cell stimulatory factor 2, p40) | 29.32 |
| CCL4 | Chemokine (C-C motif) ligand 4 | 27.97 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 26.81 |
| LOC129607 | Hypothetical protein LOC129607 | 26.46 |
| CCL8 | Chemokine (C-C motif) ligand 8 | 24.34 |
| IL8 | Interleukin 8 | 24.04 |
| ITGB8 | Integrin, beta 8 | 23.94 |
| CCR7 | Chemokine (C-C motif) receptor 7 | 23.68 |
| SOD2 | Superoxide dismutase 2, mitochondrial | 20.98 |
| ELOVL7 | ELOVL family member 7, elongation of long chain fatty acids (yeast) | 20.84 |
| MCOLN2 | Mucolipin 2 | 19.52 |
| SLAMF1 | Signaling lymphocytic activation molecule family member 1 | 17.26 |
| EGR1 | Early growth response 1 | 0.04 |
FC indicates fold change.
The 40 gene symbols with the largest IFN-α/control ratios, less than 5% false detection rate (FDR) on a posthoc test and called “present” (see “Methods”).