Table 1 Association between SNPs and MBL... | American Society of Hematology

Table 1

Association between SNPs and MBL risk

SNP	Genotype	HMDS cohort					AAUEP cohort					INGI-VB cohort
SNP	Genotype	Cases	Controls	OR	95% CI	P	Cases	Controls	OR	95% CI	P	Cases	Controls	OR	95% CI	P
rs872071	AA	48	196	1.00	Ref		14	39	1.00	Ref		15	192	1.00	Ref
6p25.3	AG	119	474	1.02	0.70-1.48	.93	42	80	1.46	0.72-3.00	.30	41	357	1.44	0.79-2.72	.22
(IRF4)	GG	83	220	1.53	1.02-2.30	.04	22	49	1.25	0.57-2.76	.58	21	143	1.88	0.94-3.77	.08
	OR_trend			1.29	1.02-1.63	.03			1.08	0.74-1.59	.66			1.39	0.98-1.98	.06
rs735665	GG	125	579	1.00	Ref		40	112	1.00	Ref		49	492	1.00	Ref
11q24.1	AG	107	282	1.76	1.31-2.36	1.77 × 10⁻⁴	34	53	1.80	1.02-3.15	.04	26	189	1.38	0.83-2.88	.21
	AA	16	27	2.75	1.44-5.25	2.29 × 10⁻³	4	2	5.60	0.99-31.76	.05	2	11	1.83	0.39-8.47	.44
	OR_trend			1.60	1.22-2.10	6.99 × 10⁻⁴			1.96	1.19-3.24	.01			1.47	0.92-2.35	.11
rs17483466	AA	137	563	1.00	Ref		46	102	1.00	Ref		48	436	1.00	Ref
2q13	AG	88	278	1.30	0.96-1.77	.09	29	53	1.21	0.69-2.15	.51	26	223	1.06	0.64-1.75	.82
	GG	23	41	2.31	1.34-3.97	2.61 × 10⁻³	3	11	0.60	0.16-2.27	.46	3	33	0.83	0.24-2.79	.76
	OR_trend			1.54	1.19-2.01	1.15 × 10⁻³			0.98	0.63-1.54	.94			0.99	0.65-1.51	.10
rs13397985	TT	126	577	1.00	Ref		50	113	1.00	Ref		42	461	1.00	Ref
2q37.1	TG	107	271	1.81	1.35-2.43	8.49 × 10⁻⁵	27	45	1.36	0.76-2.43	.31	31	198	1.72	1.05-2.81	.03
(SP140)	GG	11	29	1.74	0.85-3.57	.13	1	10	0.23	0.03-1.81	.16	4	33	1.33	0.45-3.94	.61
	OR_trend			1.57	1.20-2.09	1.28 × 10⁻³			0.96	0.59-1.54	.85			1.45	0.97-2.16	.07
rs11083846	GG	132	539	1.00	Ref		47	105	1.00	Ref		59	460	1.00	Ref
19q13.32	AG	99	291	1.39	1.03-1.87	.03	26	44	1.32	0.73-2.39	.36	17	218	0.61	0.35-1.07	.08
(PRKD2)	AA	14	52	1.10	0.59-2.04	.77	5	15	0.74	0.26-2.17	.59	1	14	0.56	0.07-4.31	.56
	OR_trend			1.11	0.85-1.44	.46			1.03	0.68-1.57	.89			0.59	0.34-1.00	.05
rs7176508	GG	77	307	1.00	Ref		24	64	1.00	Ref		25	244	1.00	Ref
15q23	AG	118	352	1.34	0.97-1.85	.08	38	79	1.28	0.70-2.36	.42	40	349	1.12	0.66-1.89	.68
	AA	42	133	1.26	0.82-1.93	.29	16	24	1.78	0.81-3.91	.15	12	99	1.18	0.57-2.45	.65
	OR_trend			1.18	0.93-1.50	.16			1.32	0.90-1.94	.16			1.07	0.75-1.54	.70
rs757978	GG	185	717	1.00	Ref		64	144	1.00	Ref		63	592	1.00	Ref
2q37.3	AG	49	146	1.30	0.91-1.87	.15	12	21	1.29	0.60-2.77	.52	12	95	1.19	0.62-2.28	.61
(FARP2)	AA	2	12	0.65	0.14-2.91	.57	2	2	2.25	0.31-16.33	.42	2	5	3.76	0.71-19.77	.12
	OR_trend			1.29	0.89-1.86	.17			1.35	0.72-2.52	.34			1.68	0.94-2.99	.08
rs305061	CC	18	87	1.00	Ref		13	26	1.00	Ref		7	104	1.00	Ref
16q24.1	TC	103	371	1.34	0.77-2.33	.30	33	91	0.73	0.33-1.58	.42	42	310	2.01	0.88-4.62	.10
	TT	113	407	1.34	0.78-2.32	.29	32	51	1.26	0.56-2.79	.58	28	278	1.50	0.63-3.53	.36
	OR_trend			1.21	0.94-1.57	.14			1.24	0.83-1.85	.30			1.03	0.72-1.47	.88
rs7169431	GG	193	746	1.00	Ref		59	137	1.00	Ref		66	611	1.00	Ref
15q21.3	AG	42	129	1.26	0.86-1.84	.24	18	28	1.49	0.77-2.91	.24	11	80	1.27	0.65-2.51	.49
	AA	1	3	1.29	0.13-12.46	.83	1	0	6.93	0.28-172.6	.24	0	1	3.10	0.12-76.00	.50
	OR_trend			1.21	0.81-1.83	.35			1.64	0.87-3.09	.12			1.20	0.59-2.42	.61
rs2456449	AA	80	367	1.00	Ref		32	85	1.00	Ref		39	377	1.00	Ref
8q24.21	AG	111	400	1.27	0.92-1.75	.14	38	70	1.44	0.82-2.54	.21	29	260	1.08	0.65-1.79	.77
	GG	40	107	1.71	1.11-2.65	.02	8	13	1.63	0.62-4.31	.32	9	55	1.58	0.73-3.44	.25
	OR_trend			1.33	1.04-1.69	.02			1.35	0.89-2.06	.16			1.25	0.87-1.80	.22

SNP	Genotype	HMDS cohort					AAUEP cohort					INGI-VB cohort
SNP	Genotype	Cases	Controls	OR	95% CI	P	Cases	Controls	OR	95% CI	P	Cases	Controls	OR	95% CI	P
rs872071	AA	48	196	1.00	Ref		14	39	1.00	Ref		15	192	1.00	Ref
6p25.3	AG	119	474	1.02	0.70-1.48	.93	42	80	1.46	0.72-3.00	.30	41	357	1.44	0.79-2.72	.22
(IRF4)	GG	83	220	1.53	1.02-2.30	.04	22	49	1.25	0.57-2.76	.58	21	143	1.88	0.94-3.77	.08
	OR_trend			1.29	1.02-1.63	.03			1.08	0.74-1.59	.66			1.39	0.98-1.98	.06
rs735665	GG	125	579	1.00	Ref		40	112	1.00	Ref		49	492	1.00	Ref
11q24.1	AG	107	282	1.76	1.31-2.36	1.77 × 10⁻⁴	34	53	1.80	1.02-3.15	.04	26	189	1.38	0.83-2.88	.21
	AA	16	27	2.75	1.44-5.25	2.29 × 10⁻³	4	2	5.60	0.99-31.76	.05	2	11	1.83	0.39-8.47	.44
	OR_trend			1.60	1.22-2.10	6.99 × 10⁻⁴			1.96	1.19-3.24	.01			1.47	0.92-2.35	.11
rs17483466	AA	137	563	1.00	Ref		46	102	1.00	Ref		48	436	1.00	Ref
2q13	AG	88	278	1.30	0.96-1.77	.09	29	53	1.21	0.69-2.15	.51	26	223	1.06	0.64-1.75	.82
	GG	23	41	2.31	1.34-3.97	2.61 × 10⁻³	3	11	0.60	0.16-2.27	.46	3	33	0.83	0.24-2.79	.76
	OR_trend			1.54	1.19-2.01	1.15 × 10⁻³			0.98	0.63-1.54	.94			0.99	0.65-1.51	.10
rs13397985	TT	126	577	1.00	Ref		50	113	1.00	Ref		42	461	1.00	Ref
2q37.1	TG	107	271	1.81	1.35-2.43	8.49 × 10⁻⁵	27	45	1.36	0.76-2.43	.31	31	198	1.72	1.05-2.81	.03
(SP140)	GG	11	29	1.74	0.85-3.57	.13	1	10	0.23	0.03-1.81	.16	4	33	1.33	0.45-3.94	.61
	OR_trend			1.57	1.20-2.09	1.28 × 10⁻³			0.96	0.59-1.54	.85			1.45	0.97-2.16	.07
rs11083846	GG	132	539	1.00	Ref		47	105	1.00	Ref		59	460	1.00	Ref
19q13.32	AG	99	291	1.39	1.03-1.87	.03	26	44	1.32	0.73-2.39	.36	17	218	0.61	0.35-1.07	.08
(PRKD2)	AA	14	52	1.10	0.59-2.04	.77	5	15	0.74	0.26-2.17	.59	1	14	0.56	0.07-4.31	.56
	OR_trend			1.11	0.85-1.44	.46			1.03	0.68-1.57	.89			0.59	0.34-1.00	.05
rs7176508	GG	77	307	1.00	Ref		24	64	1.00	Ref		25	244	1.00	Ref
15q23	AG	118	352	1.34	0.97-1.85	.08	38	79	1.28	0.70-2.36	.42	40	349	1.12	0.66-1.89	.68
	AA	42	133	1.26	0.82-1.93	.29	16	24	1.78	0.81-3.91	.15	12	99	1.18	0.57-2.45	.65
	OR_trend			1.18	0.93-1.50	.16			1.32	0.90-1.94	.16			1.07	0.75-1.54	.70
rs757978	GG	185	717	1.00	Ref		64	144	1.00	Ref		63	592	1.00	Ref
2q37.3	AG	49	146	1.30	0.91-1.87	.15	12	21	1.29	0.60-2.77	.52	12	95	1.19	0.62-2.28	.61
(FARP2)	AA	2	12	0.65	0.14-2.91	.57	2	2	2.25	0.31-16.33	.42	2	5	3.76	0.71-19.77	.12
	OR_trend			1.29	0.89-1.86	.17			1.35	0.72-2.52	.34			1.68	0.94-2.99	.08
rs305061	CC	18	87	1.00	Ref		13	26	1.00	Ref		7	104	1.00	Ref
16q24.1	TC	103	371	1.34	0.77-2.33	.30	33	91	0.73	0.33-1.58	.42	42	310	2.01	0.88-4.62	.10
	TT	113	407	1.34	0.78-2.32	.29	32	51	1.26	0.56-2.79	.58	28	278	1.50	0.63-3.53	.36
	OR_trend			1.21	0.94-1.57	.14			1.24	0.83-1.85	.30			1.03	0.72-1.47	.88
rs7169431	GG	193	746	1.00	Ref		59	137	1.00	Ref		66	611	1.00	Ref
15q21.3	AG	42	129	1.26	0.86-1.84	.24	18	28	1.49	0.77-2.91	.24	11	80	1.27	0.65-2.51	.49
	AA	1	3	1.29	0.13-12.46	.83	1	0	6.93	0.28-172.6	.24	0	1	3.10	0.12-76.00	.50
	OR_trend			1.21	0.81-1.83	.35			1.64	0.87-3.09	.12			1.20	0.59-2.42	.61
rs2456449	AA	80	367	1.00	Ref		32	85	1.00	Ref		39	377	1.00	Ref
8q24.21	AG	111	400	1.27	0.92-1.75	.14	38	70	1.44	0.82-2.54	.21	29	260	1.08	0.65-1.79	.77
	GG	40	107	1.71	1.11-2.65	.02	8	13	1.63	0.62-4.31	.32	9	55	1.58	0.73-3.44	.25
	OR_trend			1.33	1.04-1.69	.02			1.35	0.89-2.06	.16			1.25	0.87-1.80	.22

OR_trend values have been corrected for age and sex.

CI indicates confidence interval; and Ref, referent category.

View Large

This Feature Is Available To Subscribers Only