Table 2 Patient and transplant... | American Society of Hematology

Table 2

Patient and transplant characteristics of the 4 patients with donor-derived cancer

Patient	Diagnosis	Age at diagnosis, y	Treatment before transplantation	Conditioning regimen	GVHD prophylaxis	Recipient		Donor sex/relationship	Acute GVHD		Chronic GVHD		Cancer
Patient	Diagnosis	Age at diagnosis, y	Treatment before transplantation	Conditioning regimen	GVHD prophylaxis	Sex	Pregnancy	Donor sex/relationship	Grade	Treatment	Grade	Treatment	Location	Time after transplantation, y	Follow-up time interval*
I	CML	33	Hydroxyurea, splenectomy	Cy, TBI	TCD, CsA	M		F/sibling	III	ATG, steroids	Ext	CsA, steroids	Oral cavity	22	Died, cancer, 6 mo
II	SAA	21	Androgens	Cy, TBI	MTX	F	0	M/sibling	I	CsA, steroids	Ext	CsA, steroids	Oral cavity	13	Died, cancer, 8 mo
III	Fanconi	4	Steroids, androgens	Cy	MTX	F	0	F/sibling	II	CsA, steroids	Ext	CsA, steroids	Oral cavity	5	Died, cancer, 12 mo
IV	ALL	43	Chemotherapy	Cy, VP16, TBI	MTX, CsA	M		M/sibling	II	CsA, steroids	Ext	CsA, steroids	Oral cavity	7	Died, cancer, 7 mo

Patient	Diagnosis	Age at diagnosis, y	Treatment before transplantation	Conditioning regimen	GVHD prophylaxis	Recipient		Donor sex/relationship	Acute GVHD		Chronic GVHD		Cancer
Patient	Diagnosis	Age at diagnosis, y	Treatment before transplantation	Conditioning regimen	GVHD prophylaxis	Sex	Pregnancy	Donor sex/relationship	Grade	Treatment	Grade	Treatment	Location	Time after transplantation, y	Follow-up time interval*
I	CML	33	Hydroxyurea, splenectomy	Cy, TBI	TCD, CsA	M		F/sibling	III	ATG, steroids	Ext	CsA, steroids	Oral cavity	22	Died, cancer, 6 mo
II	SAA	21	Androgens	Cy, TBI	MTX	F	0	M/sibling	I	CsA, steroids	Ext	CsA, steroids	Oral cavity	13	Died, cancer, 8 mo
III	Fanconi	4	Steroids, androgens	Cy	MTX	F	0	F/sibling	II	CsA, steroids	Ext	CsA, steroids	Oral cavity	5	Died, cancer, 12 mo
IV	ALL	43	Chemotherapy	Cy, VP16, TBI	MTX, CsA	M		M/sibling	II	CsA, steroids	Ext	CsA, steroids	Oral cavity	7	Died, cancer, 7 mo

CML indicates chronic myelogenous leukemia; Cy, cyclophosphamide; TBI, total body irradiation; TCD, T-cell depletion; CsA, cyclosporine; ATG, antithymocyte globulin; Ext, extensive; SAA, severe aplastic anemia; MTX, methotrexate; ALL, acute lymphoblastic leukemia; and VP16, vepeside.

Time interval between diagnosis and death.

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