Tumor-to-normal organ ratios using conventional RIT or PRIT with Bismuth-213 at 10, 45, 90, and 180 minutes
| Organ . | 10 min . | 45 min . | 90 min . | 180 min . | ||||
|---|---|---|---|---|---|---|---|---|
| RIT . | PRIT . | RIT . | PRIT . | RIT . | PRIT . | RIT . | PRIT . | |
| Blood | 0.03 ± 0.01 | 1.75 ± 0.12 | 0.06 ± 0.01 | 16.50 ± 7.73 | 0.09 ± 0.03 | 38.31 ± 18.55 | 0.13 ± 0.03 | 25.96 ± 8.34 |
| Lung | 0.11 ± 0.05 | 2.41 ± 0.24 | 0.17 ± 0.04 | 15.25 ± 6.90 | 0.24 ± 0.08 | 24.07 ± 10.25 | 0.32 ± 0.05 | 15.89 ± 5.16 |
| Liver | 0.08 ± 0.05 | 5.20 ± 0.46 | 0.15 ± 0.10 | 18.23 ± 7.65 | 0.21 ± 0.12 | 31.83 ± 13.64 | 0.24 ± 0.11 | 19.69 ± 6.42 |
| Spleen | 0.13 ± 0.02 | 6.52 ± 0.39 | 0.2 ± 0.07 | 13.93 ± 6.08 | 0.28 ± 0.09 | 30.42 ± 17.48 | 0.49 ± 0.30 | 14.68 ± 4.31 |
| Stomach | 0.8 ± 0.10 | 8.63 ± 5.22 | 1.9 ± 0.47 | 53.49 ± 33.74 | 2.38 ± 1.08 | 98.87 ± 42.48 | 1.86 ± 0.46 | 56.39 ± 33.92 |
| Kidney | 0.11 ± 0.02 | 0.79 ± 0.04 | 0.13 ± 0.02 | 1.68 ± 0.81 | 0.14 ± 0.05 | 2.68 ± 1.02 | 0.19 ± 0.04 | 2.22 ± 0.79 |
| Small intestine | 0.87 ± 0.24 | 6.40 ± 1.24 | 0.97 ± 0.21 | 18.57 ± 9.93 | 1.09 ± 0.47 | 38.55 ± 27.51 | 1.1 ± 0.26 | 38.51 ± 12.80 |
| Colon | 2.11 ± 0.68 | 9.11 ± 0.77 | 3.29 ± 1.42 | 70.84 ± 24.40 | 2.47 ± 1.23 | 27.14 ± 13.29 | 1.11 ± 0.21 | 9.94 ± 5.47 |
| Organ . | 10 min . | 45 min . | 90 min . | 180 min . | ||||
|---|---|---|---|---|---|---|---|---|
| RIT . | PRIT . | RIT . | PRIT . | RIT . | PRIT . | RIT . | PRIT . | |
| Blood | 0.03 ± 0.01 | 1.75 ± 0.12 | 0.06 ± 0.01 | 16.50 ± 7.73 | 0.09 ± 0.03 | 38.31 ± 18.55 | 0.13 ± 0.03 | 25.96 ± 8.34 |
| Lung | 0.11 ± 0.05 | 2.41 ± 0.24 | 0.17 ± 0.04 | 15.25 ± 6.90 | 0.24 ± 0.08 | 24.07 ± 10.25 | 0.32 ± 0.05 | 15.89 ± 5.16 |
| Liver | 0.08 ± 0.05 | 5.20 ± 0.46 | 0.15 ± 0.10 | 18.23 ± 7.65 | 0.21 ± 0.12 | 31.83 ± 13.64 | 0.24 ± 0.11 | 19.69 ± 6.42 |
| Spleen | 0.13 ± 0.02 | 6.52 ± 0.39 | 0.2 ± 0.07 | 13.93 ± 6.08 | 0.28 ± 0.09 | 30.42 ± 17.48 | 0.49 ± 0.30 | 14.68 ± 4.31 |
| Stomach | 0.8 ± 0.10 | 8.63 ± 5.22 | 1.9 ± 0.47 | 53.49 ± 33.74 | 2.38 ± 1.08 | 98.87 ± 42.48 | 1.86 ± 0.46 | 56.39 ± 33.92 |
| Kidney | 0.11 ± 0.02 | 0.79 ± 0.04 | 0.13 ± 0.02 | 1.68 ± 0.81 | 0.14 ± 0.05 | 2.68 ± 1.02 | 0.19 ± 0.04 | 2.22 ± 0.79 |
| Small intestine | 0.87 ± 0.24 | 6.40 ± 1.24 | 0.97 ± 0.21 | 18.57 ± 9.93 | 1.09 ± 0.47 | 38.55 ± 27.51 | 1.1 ± 0.26 | 38.51 ± 12.80 |
| Colon | 2.11 ± 0.68 | 9.11 ± 0.77 | 3.29 ± 1.42 | 70.84 ± 24.40 | 2.47 ± 1.23 | 27.14 ± 13.29 | 1.11 ± 0.21 | 9.94 ± 5.47 |
Tumor-to-normal organ ratios using conventional RIT with 213Bi-labeled 1F5 Ab or PRIT with [213Bi]DOTA-biotin following 1F5-SA FP. Groups of 5 mice were used to generate mean values. Data were normalized for tissue weight and corrected for radioactive decay.