Chromosomal alterations in t(15;17) APL samples
| Group/case no. . | Status . | Location . | Physical localization . | Size, Mb . | Gene(s) in the region . | |
|---|---|---|---|---|---|---|
| Proximal . | Distal . | |||||
| +8 | ||||||
| 65 | Del | 4q28.1 | 125 190 507 | 126 521 903 | 1.33 | KIAA1223 |
| Del | 7q21.11-q21.12 | 85 414 972 | 86 445 002 | 1.03 | GRM3, KIAA1324L, and DMTF1 | |
| Dup | 8q24.13-q24.22 | 122 607 785 | 132 092 760 | 9.48 | > 10 genes including MYC | |
| Del | 9q12-q31.3 | 64 207 745 | 111 479 523 | 47.27 | > 10 genes | |
| 38 | Tri | Trisomy 8 | ||||
| 2 | Tri | Trisomy 8 | ||||
| Del | 10q21.2-q21.3 | 62 496 958 | 68 046 104 | 5.55 | >10 genes | |
| 50 | Del | 6p25.1-p24.3 | 5 545 437 | 8 054 930 | 2.51 | > 10 genes |
| Tri | Trisomy 8 | |||||
| 60 | Tri | Trisomy 8 | ||||
| 3 | Tri | Trisomy 8 | ||||
| CNN-LOH | 11p.ter–p11.12 | 1 938 894 | 49 879 899 | 47.9 | > 10 genes including WT1, CDKN1C and HRAS | |
| 39 | Tri | Trisomy 8 | ||||
| CNN-LOH | 10q21.1–q-ter | 59 576 047 | 135 228 726 | 75.7 | > 10 genes including PTEN and FGFR2 | |
| CNN-LOH | 11p.ter–p14.1 | 1 938 894 | 30 627 880 | 28.7 | > 10 genes including CDKN1C and HRAS | |
| 18 | Tri | Trisomy 8 | ||||
| CNN-LOH | 10q22.2–q-ter | 76 995 152 | 135 228 726 | 58.2 | > 10 genes including PTEN and FGFR2 | |
| Other | ||||||
| 66 | CNN-LOH | 10q22.2–q-ter | 76 289 513 | 135 295 604 | 59.0 | > 10 genes including PTEN and FGFR2 |
| 20 | CNN-LOH | 11p.ter–p11.12 | 1 938 894 | 49 330 228 | 47.4 | > 10 genes including WT1, CDKN1C and HRAS |
| 13 | Dup | 13q21.1–q-ter | 56 784 440 | 114 051 465 | 57.27 | > 10 genes |
| Dup | 15q22.2–q-ter | 57 244 668 | 100 182 183 | 42.94 | > 10 genes including PML | |
| 4 | CNN-LOH | 19q13.2–q-ter | 46 160 099 | 63 437 743 | 17.3 | > 10 genes |
| 37 | Del | 1q42.2 | 227 843 862 | 227 867 765 | 0.02 | EGLN1 |
| Dup | 18p11.31-p11.23 | 7 192 739 | 7 657 575 | 0.46 | PTPRM | |
| 57 | Dup | 9q22.32 | 94 435 025 | 94 710 006 | 0.27 | FBP2, FBP1, and C9orf3 |
| 19 | Del | 12p13.31-p11.22 | 6 755 671 | 29 248 257 | 22.49 | > 10 genes including ETV6 and CDKN1B |
| Del | 13q14.2-q14.3 | 49 630 676 | 50 510 777 | 0.88 | FAM10A4, DLEU7, FLJ11712, and GUCY1B2 | |
| 21 | Dup | 1q21–q-ter | 142 487 224 | 245 120 412 | 102.63 | > 10 genes |
| Del | 7q11.21–q-ter | 61 522 282 | 158 554 645 | 97.03 | > 10 genes | |
| 43 | Dup | 21q22.12–q-ter | 36 234 195 | 46 924 583 | 10.69 | >10 genes including ERG |
| 52 | Tri | Trisomy 21 | ||||
| 58 | Dup | 15q24.1–q-ter | 72 224 840 | 100 192 115 | 27.97 | > 10 genes |
| Del | 17p-ter–p11.2 | 18 901 | 21 459 693 | 21.44 | > 10 genes including TP53 | |
| Dup | 17p11.2-q21.1 | 21 491 135 | 35 542 587 | 14.05 | > 10 genes including NF1 and ERBB2 | |
| Group/case no. . | Status . | Location . | Physical localization . | Size, Mb . | Gene(s) in the region . | |
|---|---|---|---|---|---|---|
| Proximal . | Distal . | |||||
| +8 | ||||||
| 65 | Del | 4q28.1 | 125 190 507 | 126 521 903 | 1.33 | KIAA1223 |
| Del | 7q21.11-q21.12 | 85 414 972 | 86 445 002 | 1.03 | GRM3, KIAA1324L, and DMTF1 | |
| Dup | 8q24.13-q24.22 | 122 607 785 | 132 092 760 | 9.48 | > 10 genes including MYC | |
| Del | 9q12-q31.3 | 64 207 745 | 111 479 523 | 47.27 | > 10 genes | |
| 38 | Tri | Trisomy 8 | ||||
| 2 | Tri | Trisomy 8 | ||||
| Del | 10q21.2-q21.3 | 62 496 958 | 68 046 104 | 5.55 | >10 genes | |
| 50 | Del | 6p25.1-p24.3 | 5 545 437 | 8 054 930 | 2.51 | > 10 genes |
| Tri | Trisomy 8 | |||||
| 60 | Tri | Trisomy 8 | ||||
| 3 | Tri | Trisomy 8 | ||||
| CNN-LOH | 11p.ter–p11.12 | 1 938 894 | 49 879 899 | 47.9 | > 10 genes including WT1, CDKN1C and HRAS | |
| 39 | Tri | Trisomy 8 | ||||
| CNN-LOH | 10q21.1–q-ter | 59 576 047 | 135 228 726 | 75.7 | > 10 genes including PTEN and FGFR2 | |
| CNN-LOH | 11p.ter–p14.1 | 1 938 894 | 30 627 880 | 28.7 | > 10 genes including CDKN1C and HRAS | |
| 18 | Tri | Trisomy 8 | ||||
| CNN-LOH | 10q22.2–q-ter | 76 995 152 | 135 228 726 | 58.2 | > 10 genes including PTEN and FGFR2 | |
| Other | ||||||
| 66 | CNN-LOH | 10q22.2–q-ter | 76 289 513 | 135 295 604 | 59.0 | > 10 genes including PTEN and FGFR2 |
| 20 | CNN-LOH | 11p.ter–p11.12 | 1 938 894 | 49 330 228 | 47.4 | > 10 genes including WT1, CDKN1C and HRAS |
| 13 | Dup | 13q21.1–q-ter | 56 784 440 | 114 051 465 | 57.27 | > 10 genes |
| Dup | 15q22.2–q-ter | 57 244 668 | 100 182 183 | 42.94 | > 10 genes including PML | |
| 4 | CNN-LOH | 19q13.2–q-ter | 46 160 099 | 63 437 743 | 17.3 | > 10 genes |
| 37 | Del | 1q42.2 | 227 843 862 | 227 867 765 | 0.02 | EGLN1 |
| Dup | 18p11.31-p11.23 | 7 192 739 | 7 657 575 | 0.46 | PTPRM | |
| 57 | Dup | 9q22.32 | 94 435 025 | 94 710 006 | 0.27 | FBP2, FBP1, and C9orf3 |
| 19 | Del | 12p13.31-p11.22 | 6 755 671 | 29 248 257 | 22.49 | > 10 genes including ETV6 and CDKN1B |
| Del | 13q14.2-q14.3 | 49 630 676 | 50 510 777 | 0.88 | FAM10A4, DLEU7, FLJ11712, and GUCY1B2 | |
| 21 | Dup | 1q21–q-ter | 142 487 224 | 245 120 412 | 102.63 | > 10 genes |
| Del | 7q11.21–q-ter | 61 522 282 | 158 554 645 | 97.03 | > 10 genes | |
| 43 | Dup | 21q22.12–q-ter | 36 234 195 | 46 924 583 | 10.69 | >10 genes including ERG |
| 52 | Tri | Trisomy 21 | ||||
| 58 | Dup | 15q24.1–q-ter | 72 224 840 | 100 192 115 | 27.97 | > 10 genes |
| Del | 17p-ter–p11.2 | 18 901 | 21 459 693 | 21.44 | > 10 genes including TP53 | |
| Dup | 17p11.2-q21.1 | 21 491 135 | 35 542 587 | 14.05 | > 10 genes including NF1 and ERBB2 | |
Physical localization, size (Mb), and gene(s) at the chromosomal regions were obtained from UCSC Genome Browser. If known gene(s) in the chromosomal regions are less than 10, all gene names are displayed.
Copy number changes as previously described as copy number variant at Database of Genomic Variants (http://projects.tcag.ca/variation/)29 and UCSC Genome Browser (http://genome.ucsc.edu/)32 were excluded.
Del indicates deletion; Dup, duplication; Tri, trisomy; ter, terminal; and CNN-LOH, copy-number-neutral loss of heterozygosity.