Expression of integrin chains and cell-surface receptors in U1 cells
| . | Nil . | PMA . | IL-6 . |
|---|---|---|---|
| Integrin chain | |||
| αIIb (CD41) | − | − | − |
| αL (CD11a) | + | + | + |
| αE (CD103) | − | − | − |
| αM (CD11b) | − | +* | − |
| αX (CD11c) | − | +* | − |
| αV (CD51) | − | − | − |
| αVβ3 (VN-R) | − | − | − |
| αVβ5 (FN-R, VN-R) | + | + | + |
| α5β1 (FN-R) | + | + | + |
| α1 (VLA1) | − | − | − |
| α2 (CD49b) | − | − | − |
| α3 (CD49c) | − | − | − |
| α4 (CD49d) | + | + | + |
| α5 (CD49e) | + | + | + |
| α6 (CD49f) | − | +* | − |
| β1 (CD29) | + | + | + |
| β2 (CD18) | + | ++*† | + |
| β3 (CD61) | − | − | − |
| β4 (CD104) | + | + | + |
| Receptors | |||
| uPAR | + | ++* | ++* |
| FPRL1 | + | + | + |
| EGFR | − | − | − |
| . | Nil . | PMA . | IL-6 . |
|---|---|---|---|
| Integrin chain | |||
| αIIb (CD41) | − | − | − |
| αL (CD11a) | + | + | + |
| αE (CD103) | − | − | − |
| αM (CD11b) | − | +* | − |
| αX (CD11c) | − | +* | − |
| αV (CD51) | − | − | − |
| αVβ3 (VN-R) | − | − | − |
| αVβ5 (FN-R, VN-R) | + | + | + |
| α5β1 (FN-R) | + | + | + |
| α1 (VLA1) | − | − | − |
| α2 (CD49b) | − | − | − |
| α3 (CD49c) | − | − | − |
| α4 (CD49d) | + | + | + |
| α5 (CD49e) | + | + | + |
| α6 (CD49f) | − | +* | − |
| β1 (CD29) | + | + | + |
| β2 (CD18) | + | ++*† | + |
| β3 (CD61) | − | − | − |
| β4 (CD104) | + | + | + |
| Receptors | |||
| uPAR | + | ++* | ++* |
| FPRL1 | + | + | + |
| EGFR | − | − | − |
Cell-surface expression of the indicated molecules was evaluated by cytofluorimetric analysis after 24 hours of stimulation (n = 4 for all antigens except uPAR and CD11b, which were tested in 9 independent experiments). An identical pattern of expression was observed up to 72 hours after stimulation. Up-regulation of CD11b and CD11c in U937 cells stimulated with PMA was previously reported.63
VN-R indicates vitronectin receptor; FN-R, fibronectin receptor; −, negative cells; and +, positive cells.
P < .05 versus Nil.
Cells testing positive with a geometric mean fluorescence intensity greater than 2-fold that of unstimulated cells.