Table 1 Recommendations for the... | American Society of Hematology

Table 1

Recommendations for the diagnosis of ITP in children and adults

Basic evaluation	Tests of potential utility in the management of an ITP patient	Tests of unproven or uncertain benefit
Patient history	Glycoprotein-specific antibody	TPO
Family history	Antiphospholipid antibodies (including anticardiolipin and lupus anticoagulant)	Reticulated platelets
Physical examination	Antithyroid antibodies and thyroid function	PaIgG
Complete blood count and reticulocyte count	Pregnancy test in women of childbearing potential	Platelet survival study
Peripheral blood film	Antinuclear antibodies	Bleeding time
Quantitative immunoglobulin level measurement*	Viral PCR for parvovirus and CMV	Serum complement
Bone marrow examination (in selected patients; refer to text)
Blood group (Rh)
Direct antiglobulin test
H pylori†
HIV†
HCV†

Basic evaluation	Tests of potential utility in the management of an ITP patient	Tests of unproven or uncertain benefit
Patient history	Glycoprotein-specific antibody	TPO
Family history	Antiphospholipid antibodies (including anticardiolipin and lupus anticoagulant)	Reticulated platelets
Physical examination	Antithyroid antibodies and thyroid function	PaIgG
Complete blood count and reticulocyte count	Pregnancy test in women of childbearing potential	Platelet survival study
Peripheral blood film	Antinuclear antibodies	Bleeding time
Quantitative immunoglobulin level measurement*	Viral PCR for parvovirus and CMV	Serum complement
Bone marrow examination (in selected patients; refer to text)
Blood group (Rh)
Direct antiglobulin test
H pylori†
HIV†
HCV†

Refer also to supplemental Document 2.

Rh indicates rhesus; H pylori, Helicobacter pylori; HIV, human immunodeficiency virus; HCV, hepatitis C virus; PCR, polymerase chain reaction; CMV, cytomegalovirus; TPO, thrombopoietin; and PaIgG, platelet-associated immunoglobulin G.

Quantitative immunoglobulin level measurement should be considered in children with ITP and is recommended in those children with persistent or chronic ITP as part of the reassessment evaluation.

†

Recommended by the majority of the panel for adult patients regardless of geographic locale.

View Large

This Feature Is Available To Subscribers Only