Results of donor T-cell titration experiments
| Donor . | CD4+ T-cell dose, ×106 . | Survival . | Clinical scores at day +14 . |
|---|---|---|---|
| wt | 0 | 3/3 | 0.3 ± 0.2 |
| wt | 0.25 | 5/5 | 3.8 ± 0.1 |
| NIMA (oral) | 0.25 | 5/5 | 2.8 ± 0.1* |
| wt | 1 | 2/5 | 4.7 ± 0.2 |
| NIMA (oral) | 1 | 4/5 | 4.0 ± 0.2* |
| Donor . | CD4+ T-cell dose, ×106 . | Survival . | Clinical scores at day +14 . |
|---|---|---|---|
| wt | 0 | 3/3 | 0.3 ± 0.2 |
| wt | 0.25 | 5/5 | 3.8 ± 0.1 |
| NIMA (oral) | 0.25 | 5/5 | 2.8 ± 0.1* |
| wt | 1 | 2/5 | 4.7 ± 0.2 |
| NIMA (oral) | 1 | 4/5 | 4.0 ± 0.2* |
A newborn B6 mouse was fed by either a B6 mother (control) or a B6D2F1 foster mother (NIMA [oral]). Lethally irradiated B6D2F1 mice received a transplant of 5 × 106 TCD-BM from control B6 mice together with 0.25 × 106 or 106 CD4+ T cells from NIMA (oral) or controls. Survival and clinical scores after BMT are shown.
P < .05.