Antiproliferative activity of GSK690693 in cell lines derived from various hematologic malignancies
| . | Cell lines evaluated . | Sensitive cell lines . | Sensitivity, % . |
|---|---|---|---|
| Total number of unique cell lines | 112 | 62 | 55 |
| ALL | 35 | 31 | 89 |
| AML | 11 | 2 | 18 |
| CLL | 8 | 4 | 50 |
| CML | 5 | 0 | 0 |
| Burkitt lymphoma | 15 | 10 | 67 |
| Non-Hodgkin lymphoma | 11 | 8 | 73 |
| Hodgkin lymphoma | 4 | 1 | 25 |
| Others | 23 | 6 | 26 |
| . | Cell lines evaluated . | Sensitive cell lines . | Sensitivity, % . |
|---|---|---|---|
| Total number of unique cell lines | 112 | 62 | 55 |
| ALL | 35 | 31 | 89 |
| AML | 11 | 2 | 18 |
| CLL | 8 | 4 | 50 |
| CML | 5 | 0 | 0 |
| Burkitt lymphoma | 15 | 10 | 67 |
| Non-Hodgkin lymphoma | 11 | 8 | 73 |
| Hodgkin lymphoma | 4 | 1 | 25 |
| Others | 23 | 6 | 26 |
Antiproliferative activity of GSK690693 was determined in a 72-hour proliferation assay against various hematologic cell lines. Cell lines with an EC50 less than 1000 nM were classified as sensitive cells.