Table 2

HG-7-85-01 effect on cell-cycle progression

Cell linePhase, percentageHG-7-85-01, 0μMHG-7-85-01, 0.01μMHG-7-85-01, 0.1μMHG-7-85-01, 1μM
32D-BCR-ABL G0G1 37.11* 42.62* 76.52* 77.44* 
 G2M 6.88 9.56 3.78 9.07 
 S 56 47.82 19.71 13.49 
32D-BCR-ABL-T315I G0G1 25.95* 36.96* 46.35* 73.13* 
 G2M 14.59 22.64 10.54 9.29 
 S 59.46 40.40 43.11 17.59 
Ba/F3-KIT-T670I G0G1 36.62* 35.20* 29.01* 52.57* 
 G2M 13.09 14.62 16.54 10.05 
 S 50.30 50.19 54.45 37.38 
Ba/F3-PDGFRα-T674M G0G1 36.20* 40.81* 72.37* 79.92* 
 G2M 10.36 7.41 3.62 2.46 
 S 53.44 51.78 24.01 17.61 
Ba/F3-PDGFRα-T674I G0G1 49.92* 57.30* 64.90* 77.55* 
 G2M 6.46 5.98 5.82 7.16 
 S 43.61 36.72 29.28 15.29 
Cell linePhase, percentageHG-7-85-01, 0μMHG-7-85-01, 0.01μMHG-7-85-01, 0.1μMHG-7-85-01, 1μM
32D-BCR-ABL G0G1 37.11* 42.62* 76.52* 77.44* 
 G2M 6.88 9.56 3.78 9.07 
 S 56 47.82 19.71 13.49 
32D-BCR-ABL-T315I G0G1 25.95* 36.96* 46.35* 73.13* 
 G2M 14.59 22.64 10.54 9.29 
 S 59.46 40.40 43.11 17.59 
Ba/F3-KIT-T670I G0G1 36.62* 35.20* 29.01* 52.57* 
 G2M 13.09 14.62 16.54 10.05 
 S 50.30 50.19 54.45 37.38 
Ba/F3-PDGFRα-T674M G0G1 36.20* 40.81* 72.37* 79.92* 
 G2M 10.36 7.41 3.62 2.46 
 S 53.44 51.78 24.01 17.61 
Ba/F3-PDGFRα-T674I G0G1 49.92* 57.30* 64.90* 77.55* 
 G2M 6.46 5.98 5.82 7.16 
 S 43.61 36.72 29.28 15.29 

Effect of HG-7-85-01 on cell-cycle progression of BCR-ABL–, BCR-ABL-T315I–, Kit-T670I–, PDGFRα-T674M–, and PDGFRα-T674I–expressing cells after 24 hours of treatment.

*

Percentage of G0G1 values.

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