Table 2 Proximity of SIV, MLV, and ASLV... | American Society of Hematology

Table 2

Proximity of SIV, MLV, and ASLV insertions to oncogenes

	SIV									MLV			ASLV
	6-12 months SIV	Matching randoms	P vs randoms	35-47 months SIV	Matching randoms	P vs randoms	All SIV	Matching randoms	P vs randoms	All MLV	Matching randoms	P vs randoms	All ASLV	Matching randoms	P vs randoms
Total mapped integrations	289			267			519			396			198
No. of integrations within 30 kb of 1 or more oncogenes*	13	4.29	< .001	15	3.96	< .001	26	7.69	< .001	16	5.66	< .001	2	3.14	.392
No. of integrations within 30 kb of 1 or more genes†	272	152	< .001	252	140	< .001	490	273	< .001	304	202	< .001	137	107	< .001
% of sites (within 30 kb of gene) that are within 30 kb of oncogene	4.8%	2.8%	.084	5.9%	2.8%	.022	5.3%	2.8%	.014	5.3%	2.8%	.028	1.5%	2.9%	.178

	SIV									MLV			ASLV
	6-12 months SIV	Matching randoms	P vs randoms	35-47 months SIV	Matching randoms	P vs randoms	All SIV	Matching randoms	P vs randoms	All MLV	Matching randoms	P vs randoms	All ASLV	Matching randoms	P vs randoms
Total mapped integrations	289			267			519			396			198
No. of integrations within 30 kb of 1 or more oncogenes*	13	4.29	< .001	15	3.96	< .001	26	7.69	< .001	16	5.66	< .001	2	3.14	.392
No. of integrations within 30 kb of 1 or more genes†	272	152	< .001	252	140	< .001	490	273	< .001	304	202	< .001	137	107	< .001
% of sites (within 30 kb of gene) that are within 30 kb of oncogene	4.8%	2.8%	.084	5.9%	2.8%	.022	5.3%	2.8%	.014	5.3%	2.8%	.028	1.5%	2.9%	.178

Based on previously published rhesus macaque MLV and ASLV datasets (Hematti et al¹⁶; Hu et al³⁶). Bold type indicates significant at level of < .05.

As defined by the July 14, 2008, version of the Sanger Cancer Gene Census.⁴⁰

As defined by the Macaca mulatta gene set from Ensembl.³¹