Autopsy findings and blood counts in leukemic and control mice
| Donor marrow . | Spleen wgt, g . | Liver wgt, g . | WBC, 103/mm3 . | HGB, g/dL . | PLT, 103/mm3 . |
|---|---|---|---|---|---|
| Skp2+/+, p210BCR-ABL (n = 10) | 0.43 ± 0.07 | 1.65 ± 0.19 | 59.1 (9.6-142.6) | 17.7 (4.6-21) | 543 (260-806) |
| Skp2−/−, p210BCR-ABL (n = 8) | 0.29 ± 0.09 | 1.42 ± 0.32 | 7.9 (0.8-87) | 16.8 (10-19.8) | 262 (72-822) |
| Skp2+/+, empty vector (n = 4) | 0.08 ± 0.01 | 1.20 ± 0.34 | 11.7 (7.8-22.6) | 23.3 (22-25.6) | 598 (422-928) |
| Skp2−/−, empty vector (n = 2) | 0.07, 0.09 | 1.3, 1.1 | 8.8, 10.6 | 15.6, 16 | 357, 754 |
| P | .004 | NS | .02 | NS | .05 |
| Donor marrow . | Spleen wgt, g . | Liver wgt, g . | WBC, 103/mm3 . | HGB, g/dL . | PLT, 103/mm3 . |
|---|---|---|---|---|---|
| Skp2+/+, p210BCR-ABL (n = 10) | 0.43 ± 0.07 | 1.65 ± 0.19 | 59.1 (9.6-142.6) | 17.7 (4.6-21) | 543 (260-806) |
| Skp2−/−, p210BCR-ABL (n = 8) | 0.29 ± 0.09 | 1.42 ± 0.32 | 7.9 (0.8-87) | 16.8 (10-19.8) | 262 (72-822) |
| Skp2+/+, empty vector (n = 4) | 0.08 ± 0.01 | 1.20 ± 0.34 | 11.7 (7.8-22.6) | 23.3 (22-25.6) | 598 (422-928) |
| Skp2−/−, empty vector (n = 2) | 0.07, 0.09 | 1.3, 1.1 | 8.8, 10.6 | 15.6, 16 | 357, 754 |
| P | .004 | NS | .02 | NS | .05 |
Data were recorded on the day mice died or were killed due to blood counts in excess of 200 × 103/mm3 or 20% loss in body weight. P values reflect the comparison between mice transplanted with Skp2+/+ and Skp2−/− marrow infected with p210BCR-ABL.
HGB indicates hemoglobin; PLT, platelets; WBC, white blood count; wgt, weight; and NS, not significant.