Table 1

Monocyte IFNα/βR expression is independently associated with CD38 expression by memory CD8+ T cells

Control variableCorrelated variable
CD8+ T-cell CD38 expressionHIV-1 RNA loadCD4 T-cell count
CD4 −0.582 −0.260  
    P .010 .065  
HIV-1 RNA −0.726  0.494 
    P < .001  < .001 
CD4 and HIV-1 RNA −0.556   
    P .013   
CD38  −0.22 0.383 
    P  .351 .095 
HIV-1 RNA and CD38   0.322 
    P   .179 
CD4 and CD38  −0.001  
    P  .997  
Control variableCorrelated variable
CD8+ T-cell CD38 expressionHIV-1 RNA loadCD4 T-cell count
CD4 −0.582 −0.260  
    P .010 .065  
HIV-1 RNA −0.726  0.494 
    P < .001  < .001 
CD4 and HIV-1 RNA −0.556   
    P .013   
CD38  −0.22 0.383 
    P  .351 .095 
HIV-1 RNA and CD38   0.322 
    P   .179 
CD4 and CD38  −0.001  
    P  .997  

Multivariate analysis was used to determine associations between monocyte IFNα/βR expression and clinical markers of disease progression. Analysis was restricted to the subset of HIV-infected subjects for whom CD4+ T-cell count, plasma HIV RNA level, and CD38 expression by memory CD8+ T cells were all measured (n = 22). Data are shown as the partial correlation coefficients of IFNα/βR expression with each of the correlated variables shown in columns after controlling for each of the variables shown in rows. The association of IFNα/βR expression with CD38 expression by memory CD8+ T cells changes minimally after controlling for CD4+ T-cell count, HIV-1 RNA level, or both.

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