Monocyte IFNα/βR expression is independently associated with CD38 expression by memory CD8+ T cells
Control variable . | Correlated variable . | ||
---|---|---|---|
CD8+ T-cell CD38 expression . | HIV-1 RNA load . | CD4 T-cell count . | |
CD4 | −0.582 | −0.260 | |
P | .010 | .065 | |
HIV-1 RNA | −0.726 | 0.494 | |
P | < .001 | < .001 | |
CD4 and HIV-1 RNA | −0.556 | ||
P | .013 | ||
CD38 | −0.22 | 0.383 | |
P | .351 | .095 | |
HIV-1 RNA and CD38 | 0.322 | ||
P | .179 | ||
CD4 and CD38 | −0.001 | ||
P | .997 |
Control variable . | Correlated variable . | ||
---|---|---|---|
CD8+ T-cell CD38 expression . | HIV-1 RNA load . | CD4 T-cell count . | |
CD4 | −0.582 | −0.260 | |
P | .010 | .065 | |
HIV-1 RNA | −0.726 | 0.494 | |
P | < .001 | < .001 | |
CD4 and HIV-1 RNA | −0.556 | ||
P | .013 | ||
CD38 | −0.22 | 0.383 | |
P | .351 | .095 | |
HIV-1 RNA and CD38 | 0.322 | ||
P | .179 | ||
CD4 and CD38 | −0.001 | ||
P | .997 |
Multivariate analysis was used to determine associations between monocyte IFNα/βR expression and clinical markers of disease progression. Analysis was restricted to the subset of HIV-infected subjects for whom CD4+ T-cell count, plasma HIV RNA level, and CD38 expression by memory CD8+ T cells were all measured (n = 22). Data are shown as the partial correlation coefficients of IFNα/βR expression with each of the correlated variables shown in columns after controlling for each of the variables shown in rows. The association of IFNα/βR expression with CD38 expression by memory CD8+ T cells changes minimally after controlling for CD4+ T-cell count, HIV-1 RNA level, or both.