Published experience with splenic radiotherapy for myelofibrosis
| Reference . | Patients, n . | Dose, cGy . | Fractions . | Response/comments . |
|---|---|---|---|---|
| Silverstein34 | 39 | NR | NR | 63% response rate |
| Greenberger et al35 | 14 | 600 | 9 | 95% response rate; significant cytopenias in 57% |
| Slanina et al36 | 25 | NR | NR | 88% with symptomatic decrease in splenomegaly |
| Wagner et al37 | 10 | 150-300 | 6-10 | Responses in 90%; cytopenias common |
| Elliott et al38 | 23 | 277 | 7.5 | 93.9% decrease in spleen size; median duration of response 6 months; toxicities: cytopenias, complicated subsequent splenectomy |
| Bouabdallah et al39 | 15 | 980 | 22 | 59% response rate; toxicities: cytopenias |
| McFarland et al40 | 4 | 450 | 9 | All patients with a palliative response; toxicities: cytopenias |
| Reference . | Patients, n . | Dose, cGy . | Fractions . | Response/comments . |
|---|---|---|---|---|
| Silverstein34 | 39 | NR | NR | 63% response rate |
| Greenberger et al35 | 14 | 600 | 9 | 95% response rate; significant cytopenias in 57% |
| Slanina et al36 | 25 | NR | NR | 88% with symptomatic decrease in splenomegaly |
| Wagner et al37 | 10 | 150-300 | 6-10 | Responses in 90%; cytopenias common |
| Elliott et al38 | 23 | 277 | 7.5 | 93.9% decrease in spleen size; median duration of response 6 months; toxicities: cytopenias, complicated subsequent splenectomy |
| Bouabdallah et al39 | 15 | 980 | 22 | 59% response rate; toxicities: cytopenias |
| McFarland et al40 | 4 | 450 | 9 | All patients with a palliative response; toxicities: cytopenias |
NR indicates not reported.