Multivariate analysis of associations between prognostic parameters and clinical outcome in 101 young patients (< 60 years) with normal cytogenetics
| Endpoint/parameter . | Univariate analysis, P . | Multivariate analysis, P . |
|---|---|---|
| CR* | ||
| Id1 expression (continuous variable) | .01 | .02 |
| BAALC expression (continuous variable) | .01 | .03 |
| NPM1+ vs NPM− | .04 | .03 |
| Flt3/ITD+ vs Flt3/ITD− | .10 | .19 |
| AML10 vs AML12 | .31 | .45 |
| DFS† | ||
| Flt3/ITD+ vs Flt3/ITD− | .009 | .008 |
| Donor vs no donor | .01 | .01 |
| Id1 expression (continuous variable) | .02 | .02 |
| CR achieved in 1 vs 2 courses | .01 | .02 |
| NPM1+ vs NPM− | .06 | .03 |
| WBC count (continuous variable) | .07 | .60 |
| AML10 vs AML12 | .46 | .80 |
| OS‡ | ||
| Id1 expression (continuous variable) | .001 | .006 |
| CR achieved in 1 vs 2 courses | .008 | .009 |
| BAALC expression (continuous variable) | .01 | .01 |
| Flt3/ITD+ vs Flt3/ITD− | .01 | .02 |
| NPM1+ vs NPM− | .04 | .03 |
| AML10 vs AML12 | .56 | .87 |
| Endpoint/parameter . | Univariate analysis, P . | Multivariate analysis, P . |
|---|---|---|
| CR* | ||
| Id1 expression (continuous variable) | .01 | .02 |
| BAALC expression (continuous variable) | .01 | .03 |
| NPM1+ vs NPM− | .04 | .03 |
| Flt3/ITD+ vs Flt3/ITD− | .10 | .19 |
| AML10 vs AML12 | .31 | .45 |
| DFS† | ||
| Flt3/ITD+ vs Flt3/ITD− | .009 | .008 |
| Donor vs no donor | .01 | .01 |
| Id1 expression (continuous variable) | .02 | .02 |
| CR achieved in 1 vs 2 courses | .01 | .02 |
| NPM1+ vs NPM− | .06 | .03 |
| WBC count (continuous variable) | .07 | .60 |
| AML10 vs AML12 | .46 | .80 |
| OS‡ | ||
| Id1 expression (continuous variable) | .001 | .006 |
| CR achieved in 1 vs 2 courses | .008 | .009 |
| BAALC expression (continuous variable) | .01 | .01 |
| Flt3/ITD+ vs Flt3/ITD− | .01 | .02 |
| NPM1+ vs NPM− | .04 | .03 |
| AML10 vs AML12 | .56 | .87 |
Only independent parameters are sorted in order of significance.
Other parameters, such as age, WHO performance status, and CD34 expression, were not significantly associated with CR in univariate analysis and were not included in the multivariate model.
Other parameters, such as age, WHO performance status, CD34 expression, and BAALC expression, were not significantly associated with DFS in univariate analysis and were not included in the multivariate model.
Other parameters, such as age, WBC count, WHO performance status, and CD34 expression, were not significantly associated with OS in univariate analysis and were not included in the multivariate model.