Types and frequency of clonal chromosome abnormalities detected in 93 NPM1-mutated AML and 266 AML with recurrent cytogenetic abnormalities
| Karyotype . | AML . | ||||
|---|---|---|---|---|---|
| NPM1-mut* (n = 631) . | t(8;21) (n = 63) . | inv(16) (n = 37) . | t(15;17) (n = 83) . | 11q23/MLL (n = 83) . | |
| Additional abnormalities | 93/631† (14.7%) | 44/63 (69.8%) | 13/37 (35.1%) | 39/83 (47%) | 28/83 (33.7%) |
| −X/−Y | 11 | 32 | 1 | 3 | |
| +4 | 11 | 2 | 2 | ||
| −7 | 3 | ||||
| +8 | 33 | 2 | 5 | 12 | 8 |
| +13 | 2 | 2 | |||
| +19 | 4 | ||||
| +21 | 5 | 4 | |||
| +22 | 1 | 6 | 2 | ||
| del(7q) | 2 | ||||
| del(9q) | 9 | 10 | 2 | ||
| del(11q) | 2 | ||||
| ider(17)(q10)t(15;17) | 7 | ||||
| Other | 67‡ | 11 | 8 | 20 | 30 |
| Total | 142† | 59 | 22 | 44 | 52 |
| Karyotype . | AML . | ||||
|---|---|---|---|---|---|
| NPM1-mut* (n = 631) . | t(8;21) (n = 63) . | inv(16) (n = 37) . | t(15;17) (n = 83) . | 11q23/MLL (n = 83) . | |
| Additional abnormalities | 93/631† (14.7%) | 44/63 (69.8%) | 13/37 (35.1%) | 39/83 (47%) | 28/83 (33.7%) |
| −X/−Y | 11 | 32 | 1 | 3 | |
| +4 | 11 | 2 | 2 | ||
| −7 | 3 | ||||
| +8 | 33 | 2 | 5 | 12 | 8 |
| +13 | 2 | 2 | |||
| +19 | 4 | ||||
| +21 | 5 | 4 | |||
| +22 | 1 | 6 | 2 | ||
| del(7q) | 2 | ||||
| del(9q) | 9 | 10 | 2 | ||
| del(11q) | 2 | ||||
| ider(17)(q10)t(15;17) | 7 | ||||
| Other | 67‡ | 11 | 8 | 20 | 30 |
| Total | 142† | 59 | 22 | 44 | 52 |
AML with mutated NPM1.
More than one abnormality was present in a subset of cases with aberrant karyotype.
Includes 4 cases fulfilling the definition of a complex aberrant karyotype but without a typical pattern of chromosomal gains and losses:
(1) 90, XXXX, −3, +8, +8, −10, −11, −17; FLT3-ITD− (74 days, alive);
(2) 49, XY, +der(5)t(5;17)(q11;?), +8, +del(13)(q12); FLT3-ITD− (30 days, alive);
(3) 53, XX, +4, +5, +8, +8, der(12)t(12;13)(q24;q?), +16, +18, +20; FLT3-ITD+ (86 days, dead); and
(4) 55, XY, +X, +4, +5, +8, +10, +13, +14, +17, +18; FLT3-ITD+ (5 days, dead).