Summary of the regulation of KLF2 and its known downstream effects on endothelial biology
| Process . | References . |
|---|---|
| Upstream regulation | |
| Induction | |
| Shear stress | 9, 14, 15 |
| Statins | 15,–17 |
| Angiopoeitin-1 | 18 |
| AMPK | 19 |
| SIRT1 | 20 |
| Repression | |
| NF-κB | 9, 21 |
| Downstream effect | |
| Quiescence | 10, 13 |
| Anti-inflammatory | 10, 13 |
| Antithrombotic | 10, 13 |
| Antiangiogenic | 10, 22, 23 |
| Antioxidant | 24, 25 |
| Antifibrotic | 12 |
| Antiatherosclerotic | 26 |
| Development: blood vessel maturation | 27,–29 |
| Process . | References . |
|---|---|
| Upstream regulation | |
| Induction | |
| Shear stress | 9, 14, 15 |
| Statins | 15,–17 |
| Angiopoeitin-1 | 18 |
| AMPK | 19 |
| SIRT1 | 20 |
| Repression | |
| NF-κB | 9, 21 |
| Downstream effect | |
| Quiescence | 10, 13 |
| Anti-inflammatory | 10, 13 |
| Antithrombotic | 10, 13 |
| Antiangiogenic | 10, 22, 23 |
| Antioxidant | 24, 25 |
| Antifibrotic | 12 |
| Antiatherosclerotic | 26 |
| Development: blood vessel maturation | 27,–29 |
AMPK indicates AMP-activated protein kinase; KLF2, Krüppel-like factor; NF-κB, nuclear factor-κB; and SIRT1, sirtuin 1.