Table 2 Hypothetical risk of vascular... | American Society of Hematology

Table 2

Hypothetical risk of vascular complications based on the presence or absence of intravascular hemolysis and splenic function

Pathophysiologic state	Example	Risk of vascular complications
Neither hemolysis nor splenectomy	Normal person	Baseline*
Hemolysis with intact spleen	Hereditary spherocytosis Glucose-6-phosphate dehydrogenase deficiency β-thalassemia trait Other chronic hemolytic anemia	Baseline* or decreased
Splenectomy without hemolysis	Hereditary spherocytosis† Immune thrombocytopenic purpura Trauma	Increased or baseline*
Splenectomy and ongoing hemolysis‡	Thalassemia intermedia Hgb E/β-thalassemia Sickle cell anemia§ Hereditary stomatocytosis	Greatly increased

Pathophysiologic state	Example	Risk of vascular complications
Neither hemolysis nor splenectomy	Normal person	Baseline*
Hemolysis with intact spleen	Hereditary spherocytosis Glucose-6-phosphate dehydrogenase deficiency β-thalassemia trait Other chronic hemolytic anemia	Baseline* or decreased
Splenectomy without hemolysis	Hereditary spherocytosis† Immune thrombocytopenic purpura Trauma	Increased or baseline*
Splenectomy and ongoing hemolysis‡	Thalassemia intermedia Hgb E/β-thalassemia Sickle cell anemia§ Hereditary stomatocytosis	Greatly increased

Dependent on the person's unique genetic and environmental risk factors.

Very mild hemolysis may be present in some persons.

Especially intravascular hemolysis.

Nearly all patients lack functional spleens.