Tax localization at the MTOC is necessary but not sufficient for Tax-induced MTOC polarization
| Effect Tax sequence . | NF-κB activation . | MAPK activation . | Presence of Tax at the MTOC region . | MTOC polarization . |
|---|---|---|---|---|
| Wild-type | + | + | + | + |
| M7 | − | − | − | − |
| M22 | − | + | − | − |
| M47 | + | − | + | − |
| K280R | + | + | − | − |
| K284R | − | − | + | + |
| Effect Tax sequence . | NF-κB activation . | MAPK activation . | Presence of Tax at the MTOC region . | MTOC polarization . |
|---|---|---|---|---|
| Wild-type | + | + | + | + |
| M7 | − | − | − | − |
| M22 | − | + | − | − |
| M47 | + | − | + | − |
| K280R | + | + | − | − |
| K284R | − | − | + | + |
+ indicates positive; and −, negative.