Table 1 HTLV-1 Tax protein mutants and... | American Society of Hematology

Table 1

HTLV-1 Tax protein mutants and their functions

Tax mutant	Function impaired by mutation
M7 (C29A-P30S)	Failed to interact with CREB protein⁴²; Nuclear localization signal (NLS) inactivated⁴⁶
M22 (T130A-L131S)	NF-κB activation^43,47,,–50
M47 (L319R-L320S)	CREB/ATF activation^42,–44; HTLV-1 transactivation^{45,47,51,–53}
Tax (K189R)	Tax ubiquitination site^22,35
Tax (K193R)	Tax ubiquitination site^22,35
Tax (K197R)	Tax ubiquitination site^22,35
Tax (K263R)	Tax ubiquitination site^22,35
Tax (K280R)	Tax ubiquitination site^22,35
Tax (K284R)	Tax ubiquitination site^22,35
Tax (K263R-K284R)	Tax ubiquitination site^22,35
Tax (K263R-K280R-K284R)	Tax ubiquitination site^22,35

Tax mutant	Function impaired by mutation
M7 (C29A-P30S)	Failed to interact with CREB protein⁴²; Nuclear localization signal (NLS) inactivated⁴⁶
M22 (T130A-L131S)	NF-κB activation^43,47,,–50
M47 (L319R-L320S)	CREB/ATF activation^42,–44; HTLV-1 transactivation^{45,47,51,–53}
Tax (K189R)	Tax ubiquitination site^22,35
Tax (K193R)	Tax ubiquitination site^22,35
Tax (K197R)	Tax ubiquitination site^22,35
Tax (K263R)	Tax ubiquitination site^22,35
Tax (K280R)	Tax ubiquitination site^22,35
Tax (K284R)	Tax ubiquitination site^22,35
Tax (K263R-K284R)	Tax ubiquitination site^22,35
Tax (K263R-K280R-K284R)	Tax ubiquitination site^22,35