Factors associated with overall survival
| Factors associated with OS . | n . | Univariate 3-y OS % . | Multivariate model . |
|---|---|---|---|
| Age < 60 y | 40 | 77 | NS |
| Age ≥ 60 y | 59 | 58 (P = .04) | NS |
| B-symptoms absent | 83 | 68 | NS |
| B-symptoms present | 16 | 50 (P = .004) | NS |
| Rai stage 0 | 33 | 88 | |
| Rai stage 1-2 | 48 | 59 | |
| Rai stage 3-4 | 18 | 30 (P < .001) | HR 4.4 for Rai stage ≥ 1 (P = .02) |
| White cell count < 50 × 109/L | 59 | 73 | NS |
| White cell count ≥ 50 × 109/L | 40 | 53 (P = .02) | NS |
| β2m < 2 × upper limit normal | 49 | 77 | NS |
| β2m ≥ 2 × upper limit normal | 34 | 45 (P = .002) | NS |
| FISH 17p− Q1 (< 25%) | 28 | 92 | |
| FISH 17p− Q2 (25%-49%) | 16 | 56 | |
| FISH 17p− Q3 (50%-74%) | 18 | 79 | |
| FISH 17p− Q4 (≥ 75%) | 37 | 40 (P = .003) | HR 5.2 for FISH 17p− > 25% (P = .03) |
| Mutated IgVH | 29 | 89 | |
| Unmutated IgVH | 54 | 47 (P = .002) | HR 5.5 for unmutated IgVH (P = .01) |
| Factors associated with OS . | n . | Univariate 3-y OS % . | Multivariate model . |
|---|---|---|---|
| Age < 60 y | 40 | 77 | NS |
| Age ≥ 60 y | 59 | 58 (P = .04) | NS |
| B-symptoms absent | 83 | 68 | NS |
| B-symptoms present | 16 | 50 (P = .004) | NS |
| Rai stage 0 | 33 | 88 | |
| Rai stage 1-2 | 48 | 59 | |
| Rai stage 3-4 | 18 | 30 (P < .001) | HR 4.4 for Rai stage ≥ 1 (P = .02) |
| White cell count < 50 × 109/L | 59 | 73 | NS |
| White cell count ≥ 50 × 109/L | 40 | 53 (P = .02) | NS |
| β2m < 2 × upper limit normal | 49 | 77 | NS |
| β2m ≥ 2 × upper limit normal | 34 | 45 (P = .002) | NS |
| FISH 17p− Q1 (< 25%) | 28 | 92 | |
| FISH 17p− Q2 (25%-49%) | 16 | 56 | |
| FISH 17p− Q3 (50%-74%) | 18 | 79 | |
| FISH 17p− Q4 (≥ 75%) | 37 | 40 (P = .003) | HR 5.2 for FISH 17p− > 25% (P = .03) |
| Mutated IgVH | 29 | 89 | |
| Unmutated IgVH | 54 | 47 (P = .002) | HR 5.5 for unmutated IgVH (P = .01) |
Variables that had no significant impact on overall survival: institution (M. D. Anderson vs Mayo Clinic), sex, time from initial diagnosis, performance status, conventional cytogenetics, presence of other FISH abnormalities, CD38 expression, and ZAP-70 expression.
OS indicates overall survival; FISH, fluorescent in situ hybridization; HR, hazard ration; IgVH, immunoglobulin variable region heavy chain; and NS, not significant.