Factors studied in the univariate analysis for predicting survival in patients who received HU
| Variable . | Odds ratio (P) . | 95% CI . |
|---|---|---|
| Age, y (continuous variable) | 0.992 (.792) | 0.935-1.053 |
| Hemoglobin dichotomous variable (> 9 g/dL), continuous variable | 0.593 (.374) | 0.187-1.876 |
| 0.883 (.528) | 0.601-1.299 | |
| HbF dichotomous variable (> 2%), continuous variable | 0.243 (.038) | 0.064-0.922 |
| 0.945 (.441) | 0.817-1.092 | |
| White blood cell counts dichotomous variable (> 8 × 109/L), continuous variable | 1.465 (.567) | 0.396-5.419 |
| 1.000 (.496) | 1.000-1.000 | |
| Platelet counts dichotomous variable (> 100 × 109/L), continuous variable | 0.786 (.683) | 0.247-2.497 |
| 1.000 (.563) | 1.000-1.000 | |
| Reticulocyte counts dichotomous variable (< 2%), continuous variable | 0.106 (.005) | 0.022-0.502 |
| 1.014 (.723) | 0.940-1.093 | |
| Bilirubin dichotomous variable (> 1.2 mg/dL), continuous variable | 0.931 (.916) | 0.250-3.472 |
| 1.094 (.056) | 0.998-1.200 | |
| LDH dichotomous variable (> 800 U/L), continuous variable | 0.892 (.723) | 0.267-2.150 |
| 0.999 (.425) | 0.997-1.001 | |
| Percent change of Hb between baseline and 6th month (continuous variable) | 0.997 (.873) | 0.959-1.036 |
| Percent change of WBC between baseline and 6th month (continuous variable) | 0.992 (.448) | 0.972-1.013 |
| Percent change of PLT between baseline and 6th month (continuous variable) | 0.993 (.399) | 0.977-1.009 |
| Percent change of HbF between baseline and 6th month (continuous variable) | 1.001 (.241) | 0.999-1.002 |
| Percent change of reticulocytes between baseline and 6th month (continuous variable) | 1.002 (.507) | 0.997-1.007 |
| Percent change of Bil between baseline and 6th month (continuous variable) | 1.001 (.754) | 0.996-1.006 |
| Percent change of LDH between baseline and 6th month (continuous variable) | 1.008 (.032) | 1.001-1.016 |
| Variable . | Odds ratio (P) . | 95% CI . |
|---|---|---|
| Age, y (continuous variable) | 0.992 (.792) | 0.935-1.053 |
| Hemoglobin dichotomous variable (> 9 g/dL), continuous variable | 0.593 (.374) | 0.187-1.876 |
| 0.883 (.528) | 0.601-1.299 | |
| HbF dichotomous variable (> 2%), continuous variable | 0.243 (.038) | 0.064-0.922 |
| 0.945 (.441) | 0.817-1.092 | |
| White blood cell counts dichotomous variable (> 8 × 109/L), continuous variable | 1.465 (.567) | 0.396-5.419 |
| 1.000 (.496) | 1.000-1.000 | |
| Platelet counts dichotomous variable (> 100 × 109/L), continuous variable | 0.786 (.683) | 0.247-2.497 |
| 1.000 (.563) | 1.000-1.000 | |
| Reticulocyte counts dichotomous variable (< 2%), continuous variable | 0.106 (.005) | 0.022-0.502 |
| 1.014 (.723) | 0.940-1.093 | |
| Bilirubin dichotomous variable (> 1.2 mg/dL), continuous variable | 0.931 (.916) | 0.250-3.472 |
| 1.094 (.056) | 0.998-1.200 | |
| LDH dichotomous variable (> 800 U/L), continuous variable | 0.892 (.723) | 0.267-2.150 |
| 0.999 (.425) | 0.997-1.001 | |
| Percent change of Hb between baseline and 6th month (continuous variable) | 0.997 (.873) | 0.959-1.036 |
| Percent change of WBC between baseline and 6th month (continuous variable) | 0.992 (.448) | 0.972-1.013 |
| Percent change of PLT between baseline and 6th month (continuous variable) | 0.993 (.399) | 0.977-1.009 |
| Percent change of HbF between baseline and 6th month (continuous variable) | 1.001 (.241) | 0.999-1.002 |
| Percent change of reticulocytes between baseline and 6th month (continuous variable) | 1.002 (.507) | 0.997-1.007 |
| Percent change of Bil between baseline and 6th month (continuous variable) | 1.001 (.754) | 0.996-1.006 |
| Percent change of LDH between baseline and 6th month (continuous variable) | 1.008 (.032) | 1.001-1.016 |
Bil indicates bilirubin; CI, confidence interval; HbF, hemoglobin F; HU, hydroxyurea; LDH, lactate dehydrogenase; PLT, platelets; WBC, white blood cells.