Clinical and immunologic parameters of MC patients with active and nonactive cutaneous vasculitis
| Parameter . | Cutaneous vasculitis . | |
|---|---|---|
| Active (n = 9) . | Nonactive (n = 11) . | |
| Purpura, % | 9 (100) | 0 |
| Urticarial lesions, % | 3 (33) | 0 |
| Livedo reticularis, % | 2 (22) | 0 |
| Leg ulcers, % | 6 (66) | 0 |
| Cryocrit, % (mean ± SD) | 3.76 ± 1.2 | 8.14 ± 2.8 |
| Cryoglobulin immunochemical types, % | ||
| Type II | 8 | 8 |
| Type III | 1 | 3 |
| γ -Globulin levels (mean ± SD; normal values, 0.7-1.8 g/dL) | 1.16 ± 0.7 | 1.13 ± 0.9 |
| Serum IgM (mean ± SD; normal values, 40-230 mg/dL) | 400 ± 114 | 413 ± 190 |
| RF activity (mean ± SD; normal values, ≤ 20 IU/mL) | 390 ± 110 | 415 ± 167 |
| Complement C4 (mean ± SD; normal values, 20-40 mg/dL) | 4.1 ± 2.1 | 5.3 ± 1.9 |
| CXCL13 serum concentration, pg/mL (mean ± SD) | 325 ± 160* | 112 ± 32 |
| Peripheral neuropathy, % | 4 (44) | 3 (27) |
| Nephropathy, % | 2 (22) | 2 (18) |
| Parameter . | Cutaneous vasculitis . | |
|---|---|---|
| Active (n = 9) . | Nonactive (n = 11) . | |
| Purpura, % | 9 (100) | 0 |
| Urticarial lesions, % | 3 (33) | 0 |
| Livedo reticularis, % | 2 (22) | 0 |
| Leg ulcers, % | 6 (66) | 0 |
| Cryocrit, % (mean ± SD) | 3.76 ± 1.2 | 8.14 ± 2.8 |
| Cryoglobulin immunochemical types, % | ||
| Type II | 8 | 8 |
| Type III | 1 | 3 |
| γ -Globulin levels (mean ± SD; normal values, 0.7-1.8 g/dL) | 1.16 ± 0.7 | 1.13 ± 0.9 |
| Serum IgM (mean ± SD; normal values, 40-230 mg/dL) | 400 ± 114 | 413 ± 190 |
| RF activity (mean ± SD; normal values, ≤ 20 IU/mL) | 390 ± 110 | 415 ± 167 |
| Complement C4 (mean ± SD; normal values, 20-40 mg/dL) | 4.1 ± 2.1 | 5.3 ± 1.9 |
| CXCL13 serum concentration, pg/mL (mean ± SD) | 325 ± 160* | 112 ± 32 |
| Peripheral neuropathy, % | 4 (44) | 3 (27) |
| Nephropathy, % | 2 (22) | 2 (18) |
MC indicates mixed cryoglobulinemia; IgM, immunoglobulin M; and RF, rheumatoid factor.
P < .001.