Bioactive pharmacologic classes by phenotype
| Class* . | Total agents . | Screen . | Cytotoxicity . | Lethality . | Edema . | Pigmentation . | Other . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total active . | Active agents . | Percentage of total . | Active agents . | Percentage of total . | Active agents . | Percentage of total . | Active agents . | Percentage of total . | Active agents . | Percentage of total . | ||
| Adenosine | 55 | 3 | — | — | — | — | 3 | 5.5 | — | — | — | — |
| Adrenoreceptor | 104 | 2 | — | — | — | — | 1 | 1.0 | 1 | 1.0 | — | — |
| Antibiotic | 28 | 3 | 1 | 3.6 | — | — | 1 | 3.6 | 1 | 3.6 | — | — |
| Apoptosis | 12 | 4 | 1 | 8.3 | — | — | 2 | 16.7 | — | — | 1 | 8.3 |
| Biochemistry | 46 | 2 | 1 | 2.2 | — | — | 1 | 2.2 | — | — | — | — |
| Ca2+ channel | 18 | 8 | — | — | 2 | 11.1 | 6 | 33.3 | — | — | — | — |
| Cannabinoid | 6 | 1 | 1 | 16.7 | — | — | — | — | — | — | — | — |
| Cell cycle | 15 | 3 | 1 | 6.7 | 1 | 6.7 | — | — | 1 | 6.7 | — | — |
| Cell stress | 19 | 3 | 1 | 5.3 | — | — | 1 | 5.3 | — | — | 1 | 5.3 |
| Cholinergic | 77 | 2 | 1 | 1.3 | 1 | 1.3 | — | — | — | — | — | — |
| Cl− channel | 3 | 1 | 1 | 33.3 | — | — | — | — | — | — | — | — |
| Cyclic nucleotides | 31 | 3 | — | — | — | — | 3 | 9.7 | — | — | — | — |
| Cytoskeleton and ECM | 10 | 3 | 1 | 10.0 | — | — | 2 | 20.0 | — | — | — | — |
| Dopamine | 114 | 9 | 1 | 0.9 | — | — | 3 | 2.6 | 5 | 4.4 | — | — |
| G protein | 4 | 1 | 1 | 25.0 | — | — | — | — | — | — | — | — |
| GABA | 42 | 1 | — | — | — | — | — | — | — | — | 1 | 2.4 |
| Gene regulation | 1 | 1 | — | — | — | — | 1 | 100.0 | — | — | — | — |
| Glutamate | 88 | 1 | — | — | — | — | 1 | 1.1 | — | — | — | — |
| Histamine | 31 | 2 | — | — | 1 | 3.2 | 1 | 3.2 | — | — | — | — |
| Hormone | 34 | 4 | — | — | 1 | 2.9 | 2 | 5.9 | — | — | 1 | 2.9 |
| Intracellular calcium | 8 | 3 | 2 | 25.0 | 1 | 12.5 | — | — | — | — | — | — |
| Ion pump | 17 | 1 | 1 | 5.9 | — | — | — | — | — | — | — | — |
| K+ channel | 19 | 1 | — | — | — | — | 1 | 5.3 | — | — | — | — |
| Leukotriene | 10 | 3 | 2 | 20.0 | 1 | 10.0 | — | — | — | — | — | — |
| Lipid | 10 | 3 | 2 | 20.0 | 1 | 10.0 | — | — | — | — | — | — |
| Multidrug resistance | 12 | 1 | — | — | — | — | — | — | — | — | 1 | 8.3 |
| Neurotransmission | 46 | 3 | 1 | 2.2 | 2 | 4.3 | — | — | — | — | — | — |
| Nitric oxide | 37 | 1 | — | — | — | — | — | — | — | — | 1 | 2.7 |
| Phosphorylation | 92 | 30 | 11 | 12.0 | 6 | 5.5 | 13 | 14.1 | — | — | — | — |
| Prostaglandin | 24 | 2 | — | — | 1 | 4.2 | 1 | 4.2 | — | — | — | — |
| Serotonin | 87 | 3 | — | — | — | — | 2 | 2.3 | 1 | 1.1 | — | — |
| Tachykinin | 5 | 1 | — | — | — | — | — | — | 1 | 20 | — | — |
| Thromboxane | 2 | 1 | 1 | 50.0 | — | — | — | — | — | — | — | — |
| Transcription | 12 | 4 | 1 | 8.3 | — | — | 3 | 25.0 | — | — | — | — |
| Entire screen | 1280 | 114 | 32 | 2.5† | 18 | 1.4† | 48 | 3.8† | 10 | 0.8† | 6 | 0.5† |
| Class* . | Total agents . | Screen . | Cytotoxicity . | Lethality . | Edema . | Pigmentation . | Other . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total active . | Active agents . | Percentage of total . | Active agents . | Percentage of total . | Active agents . | Percentage of total . | Active agents . | Percentage of total . | Active agents . | Percentage of total . | ||
| Adenosine | 55 | 3 | — | — | — | — | 3 | 5.5 | — | — | — | — |
| Adrenoreceptor | 104 | 2 | — | — | — | — | 1 | 1.0 | 1 | 1.0 | — | — |
| Antibiotic | 28 | 3 | 1 | 3.6 | — | — | 1 | 3.6 | 1 | 3.6 | — | — |
| Apoptosis | 12 | 4 | 1 | 8.3 | — | — | 2 | 16.7 | — | — | 1 | 8.3 |
| Biochemistry | 46 | 2 | 1 | 2.2 | — | — | 1 | 2.2 | — | — | — | — |
| Ca2+ channel | 18 | 8 | — | — | 2 | 11.1 | 6 | 33.3 | — | — | — | — |
| Cannabinoid | 6 | 1 | 1 | 16.7 | — | — | — | — | — | — | — | — |
| Cell cycle | 15 | 3 | 1 | 6.7 | 1 | 6.7 | — | — | 1 | 6.7 | — | — |
| Cell stress | 19 | 3 | 1 | 5.3 | — | — | 1 | 5.3 | — | — | 1 | 5.3 |
| Cholinergic | 77 | 2 | 1 | 1.3 | 1 | 1.3 | — | — | — | — | — | — |
| Cl− channel | 3 | 1 | 1 | 33.3 | — | — | — | — | — | — | — | — |
| Cyclic nucleotides | 31 | 3 | — | — | — | — | 3 | 9.7 | — | — | — | — |
| Cytoskeleton and ECM | 10 | 3 | 1 | 10.0 | — | — | 2 | 20.0 | — | — | — | — |
| Dopamine | 114 | 9 | 1 | 0.9 | — | — | 3 | 2.6 | 5 | 4.4 | — | — |
| G protein | 4 | 1 | 1 | 25.0 | — | — | — | — | — | — | — | — |
| GABA | 42 | 1 | — | — | — | — | — | — | — | — | 1 | 2.4 |
| Gene regulation | 1 | 1 | — | — | — | — | 1 | 100.0 | — | — | — | — |
| Glutamate | 88 | 1 | — | — | — | — | 1 | 1.1 | — | — | — | — |
| Histamine | 31 | 2 | — | — | 1 | 3.2 | 1 | 3.2 | — | — | — | — |
| Hormone | 34 | 4 | — | — | 1 | 2.9 | 2 | 5.9 | — | — | 1 | 2.9 |
| Intracellular calcium | 8 | 3 | 2 | 25.0 | 1 | 12.5 | — | — | — | — | — | — |
| Ion pump | 17 | 1 | 1 | 5.9 | — | — | — | — | — | — | — | — |
| K+ channel | 19 | 1 | — | — | — | — | 1 | 5.3 | — | — | — | — |
| Leukotriene | 10 | 3 | 2 | 20.0 | 1 | 10.0 | — | — | — | — | — | — |
| Lipid | 10 | 3 | 2 | 20.0 | 1 | 10.0 | — | — | — | — | — | — |
| Multidrug resistance | 12 | 1 | — | — | — | — | — | — | — | — | 1 | 8.3 |
| Neurotransmission | 46 | 3 | 1 | 2.2 | 2 | 4.3 | — | — | — | — | — | — |
| Nitric oxide | 37 | 1 | — | — | — | — | — | — | — | — | 1 | 2.7 |
| Phosphorylation | 92 | 30 | 11 | 12.0 | 6 | 5.5 | 13 | 14.1 | — | — | — | — |
| Prostaglandin | 24 | 2 | — | — | 1 | 4.2 | 1 | 4.2 | — | — | — | — |
| Serotonin | 87 | 3 | — | — | — | — | 2 | 2.3 | 1 | 1.1 | — | — |
| Tachykinin | 5 | 1 | — | — | — | — | — | — | 1 | 20 | — | — |
| Thromboxane | 2 | 1 | 1 | 50.0 | — | — | — | — | — | — | — | — |
| Transcription | 12 | 4 | 1 | 8.3 | — | — | 3 | 25.0 | — | — | — | — |
| Entire screen | 1280 | 114 | 32 | 2.5† | 18 | 1.4† | 48 | 3.8† | 10 | 0.8† | 6 | 0.5† |