Mutations in NHD13 acute leukemias
| Mouse . | Strain . | Age, mo . | Diagnosis . | Genes . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| NpmI . | p53 . | Runx1 . | Cbl . | Flt3 . | Kit . | K-ras . | N-Ras . | ||||
| 63 | C57BL6 | 11 | AML with maturation | GL | GL | GL | GL | GL | GL | GL | GL |
| 251 | C57BL6 | 9 | AML with maturation | GL | GL | ND | GL | GL | GL | GL | codon 12 GGT>GAT (G>D) |
| 254 | C57BL6 | 11 | AML with maturation | GL | GL | GL | GL | GL | GL | GL | GL |
| 1135 | C57BL6 | 12 | AML with maturation | GL | GL | GL | GL | GL | GL | codon 12 GGT>GAT (G>D) | GL |
| 2434 | C57BL6 | 13 | AML with maturation | GL | GL | GL | GL | GL | GL | GL | codon 12 GGT>AGT (G>S) |
| 2437 | C57BL6 | 13 | AML with maturation | GL | ND | GL | GL | GL | GL | GL | GL |
| 2554 | C57BL6 | 12 | AML with maturation | GL | ND | GL | GL | GL | GL | GL | GL |
| 1079 | C57BL6 | 10 | AML with maturation | GL | GL | GL | GL | GL | GL | GL | GL |
| 1080 | C57BL6 | 10 | AML with maturation | GL | ND | GL | 297 bp deletion | GL | GL | GL | GL |
| 1134 | C57BL6 | 10 | AML without maturation | GL | GL | GL | GL | GL | GL | GL | GL |
| 1155 | C57BL6 | 10 | AML without maturation | GL | GL | GL | GL | GL | GL | GL | GL |
| 2413 | C57BL6 | 8 | AML without maturation | GL | GL | GL | GL | GL | GL | GL | GL |
| 2417 | C57BL6 | 9 | AML without maturation | GL | GL | GL | GL | GL | GL | codon 12 GGT>GAT (G>D) | GL |
| 2420 | C57BL6 | 14 | AML without maturation | GL | GL | GL | GL | GL | GL | GL | GL |
| 1892 | C57BL6 | 11 | MPD-like leukemia | GL | GL | GL | GL | GL | GL | GL | codon 12 GGT>GAT (G>D) |
| 2590 | C57BL6 | 5 | MPD-like leukemia | GL | ND | GL | GL | GL | GL | GL | GL |
| 2679 | C57BL6 | 6 | MPD-like leukemia | GL | GL | GL | GL | GL | GL | GL | GL |
| 1017 | FVB | 9 | AMKL | GL | GL | GL | GL | GL | GL | codon 12 GGT>GTT (G>V) | GL |
| 1668 | FVB | 10 | AML with maturation | GL | GL | GL | GL | GL | GL | GL | GL |
| 4875 | FVB | 15 | AML with maturation | GL | GL | GL | GL | GL | GL | GL | GL |
| 1019 | FVB | 14 | AML with maturation | GL | GL | GL | GL | GL | GL | codon 12 GGT>GTT (G>V) | GL |
| 1018 | FVB | 14 | Erythroid leukemia (spleen) | GL | GL | GL | GL | GL | GL | GL | GL |
| 1138 | C57BL6 | 8 | Biphenotypic pre-T LBL/AML | ND | ND | ND | ND | ND | ND | GL | GL |
| 2423 | C57BL6 | 8 | Biphenotypic pre-T LBL/AML | ND | ND | ND | ND | ND | ND | GL | GL |
| 2553 | C57BL6 | 10 | pre-T LBL | ND | ND | ND | ND | ND | ND | GL | GL |
| 2410 | C57BL6 | 11 | pre-T LBL | ND | ND | ND | ND | ND | ND | GL | GL |
| 1075 | FVB | 8 | pre-T LBL | ND | ND | ND | ND | ND | ND | GL | GL |
| 1901 | FVB | 10 | pre-T LBL | ND | ND | ND | ND | ND | ND | GL | codon 61 CAA>AAA (Q>K) |
| 2738 | FVB | 7 | pre-T LBL | ND | ND | ND | ND | ND | ND | GL | GL |
| 2918 | FVB | 6 | pre-T LBL | ND | ND | ND | ND | ND | ND | GL | GL |
| 8013 | FVB | 9 | pre-T LBL | ND | ND | ND | ND | ND | ND | GL | GL |
| 1018 | FVB | 14 | pre-T LBL (thymus) | ND | ND | ND | ND | ND | ND | codon 12 GGT>GAT (G>D) | GL |
| Mouse . | Strain . | Age, mo . | Diagnosis . | Genes . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| NpmI . | p53 . | Runx1 . | Cbl . | Flt3 . | Kit . | K-ras . | N-Ras . | ||||
| 63 | C57BL6 | 11 | AML with maturation | GL | GL | GL | GL | GL | GL | GL | GL |
| 251 | C57BL6 | 9 | AML with maturation | GL | GL | ND | GL | GL | GL | GL | codon 12 GGT>GAT (G>D) |
| 254 | C57BL6 | 11 | AML with maturation | GL | GL | GL | GL | GL | GL | GL | GL |
| 1135 | C57BL6 | 12 | AML with maturation | GL | GL | GL | GL | GL | GL | codon 12 GGT>GAT (G>D) | GL |
| 2434 | C57BL6 | 13 | AML with maturation | GL | GL | GL | GL | GL | GL | GL | codon 12 GGT>AGT (G>S) |
| 2437 | C57BL6 | 13 | AML with maturation | GL | ND | GL | GL | GL | GL | GL | GL |
| 2554 | C57BL6 | 12 | AML with maturation | GL | ND | GL | GL | GL | GL | GL | GL |
| 1079 | C57BL6 | 10 | AML with maturation | GL | GL | GL | GL | GL | GL | GL | GL |
| 1080 | C57BL6 | 10 | AML with maturation | GL | ND | GL | 297 bp deletion | GL | GL | GL | GL |
| 1134 | C57BL6 | 10 | AML without maturation | GL | GL | GL | GL | GL | GL | GL | GL |
| 1155 | C57BL6 | 10 | AML without maturation | GL | GL | GL | GL | GL | GL | GL | GL |
| 2413 | C57BL6 | 8 | AML without maturation | GL | GL | GL | GL | GL | GL | GL | GL |
| 2417 | C57BL6 | 9 | AML without maturation | GL | GL | GL | GL | GL | GL | codon 12 GGT>GAT (G>D) | GL |
| 2420 | C57BL6 | 14 | AML without maturation | GL | GL | GL | GL | GL | GL | GL | GL |
| 1892 | C57BL6 | 11 | MPD-like leukemia | GL | GL | GL | GL | GL | GL | GL | codon 12 GGT>GAT (G>D) |
| 2590 | C57BL6 | 5 | MPD-like leukemia | GL | ND | GL | GL | GL | GL | GL | GL |
| 2679 | C57BL6 | 6 | MPD-like leukemia | GL | GL | GL | GL | GL | GL | GL | GL |
| 1017 | FVB | 9 | AMKL | GL | GL | GL | GL | GL | GL | codon 12 GGT>GTT (G>V) | GL |
| 1668 | FVB | 10 | AML with maturation | GL | GL | GL | GL | GL | GL | GL | GL |
| 4875 | FVB | 15 | AML with maturation | GL | GL | GL | GL | GL | GL | GL | GL |
| 1019 | FVB | 14 | AML with maturation | GL | GL | GL | GL | GL | GL | codon 12 GGT>GTT (G>V) | GL |
| 1018 | FVB | 14 | Erythroid leukemia (spleen) | GL | GL | GL | GL | GL | GL | GL | GL |
| 1138 | C57BL6 | 8 | Biphenotypic pre-T LBL/AML | ND | ND | ND | ND | ND | ND | GL | GL |
| 2423 | C57BL6 | 8 | Biphenotypic pre-T LBL/AML | ND | ND | ND | ND | ND | ND | GL | GL |
| 2553 | C57BL6 | 10 | pre-T LBL | ND | ND | ND | ND | ND | ND | GL | GL |
| 2410 | C57BL6 | 11 | pre-T LBL | ND | ND | ND | ND | ND | ND | GL | GL |
| 1075 | FVB | 8 | pre-T LBL | ND | ND | ND | ND | ND | ND | GL | GL |
| 1901 | FVB | 10 | pre-T LBL | ND | ND | ND | ND | ND | ND | GL | codon 61 CAA>AAA (Q>K) |
| 2738 | FVB | 7 | pre-T LBL | ND | ND | ND | ND | ND | ND | GL | GL |
| 2918 | FVB | 6 | pre-T LBL | ND | ND | ND | ND | ND | ND | GL | GL |
| 8013 | FVB | 9 | pre-T LBL | ND | ND | ND | ND | ND | ND | GL | GL |
| 1018 | FVB | 14 | pre-T LBL (thymus) | ND | ND | ND | ND | ND | ND | codon 12 GGT>GAT (G>D) | GL |
MPD-like leukemia indicates myeloproliferative disease-like leukemia; AMKL, acute megakaryocytic leukemia; GL, germline; and ND, not done.