Summary of results from 18 bioinformatics methods applied to 17 amino acid substitutions observed in TACI in either this study or earlier studies
| Substitution . | Seq conserv . | Stability center . | Disorder . | Energy change . | Steric clashes . | β-Aggregation . | Reference . |
|---|---|---|---|---|---|---|---|
| W40R | XX | X | NA | NA | This study | ||
| D41H | XX | NA | NA | This study | |||
| R72H | XX | This study, 10,24 | |||||
| Y79C | XX | X | This study | ||||
| I87N | XX | X | XX | This study | |||
| C104R | XX | X | XX | X | This study, 10,11,24,25,29 | ||
| C104Y | XX | XX | X | This study | |||
| R122W | XX | X | NA | NA | 25 | ||
| A149T | NA | NA | This study | ||||
| G152E | XX | NA | NA | This study | |||
| L171R | X | NA | NA | 24,29 | |||
| C172Y | XX | X | NA | NA | X | 29 | |
| A181E | X | X | NA | NA | This study, 10,11,24,25,29 | ||
| R202H | X | NA | NA | 10,11,25 | |||
| V220A | X | NA | NA | This study, 10,11,24,25 | |||
| V246F | X | NA | NA | This study | |||
| P251L | XX | NA | NA | This study, 10,11,24,25 |
| Substitution . | Seq conserv . | Stability center . | Disorder . | Energy change . | Steric clashes . | β-Aggregation . | Reference . |
|---|---|---|---|---|---|---|---|
| W40R | XX | X | NA | NA | This study | ||
| D41H | XX | NA | NA | This study | |||
| R72H | XX | This study, 10,24 | |||||
| Y79C | XX | X | This study | ||||
| I87N | XX | X | XX | This study | |||
| C104R | XX | X | XX | X | This study, 10,11,24,25,29 | ||
| C104Y | XX | XX | X | This study | |||
| R122W | XX | X | NA | NA | 25 | ||
| A149T | NA | NA | This study | ||||
| G152E | XX | NA | NA | This study | |||
| L171R | X | NA | NA | 24,29 | |||
| C172Y | XX | X | NA | NA | X | 29 | |
| A181E | X | X | NA | NA | This study, 10,11,24,25,29 | ||
| R202H | X | NA | NA | 10,11,25 | |||
| V220A | X | NA | NA | This study, 10,11,24,25 | |||
| V246F | X | NA | NA | This study | |||
| P251L | XX | NA | NA | This study, 10,11,24,25 |
For categories in which there were numerous methods, we distinguish between XX (consensus of the methods predicts that this change is deleterious), X (some methods predict that the change is deleterious and some do not), and no mark (most if not all methods predict that the change is benign). This table is a compilation of summaries of results that can be found in Tables S1 through S16.
Seq conserv indicates sequence conservation; and NA, not available.