Morphometric analysis of allografts at day 21 after transplantation
| . | SR-BI+/+ bone marrow . | SR-BI−/− bone marrow . | ||
|---|---|---|---|---|
| Controls . | AdA-I . | Controls . | AdA-I . | |
| No. of mice | 18 | 21 | 14 | 17 |
| Area within the external elastic lamina | 150 ± 9.9 | 140 ± 8.1 | 140 ± 10 | 150 ± 8.5 |
| Area within the internal elastic lamina | 89 ± 7.2 | 78 ± 4.7 | 94 ± 9.2 | 87 ± 4.9 |
| Medial area | 66 ± 4.0 | 62 ± 4.6 | 55 ± 4.7 | 59 ± 5.0 |
| Intimal area | 70 ± 8.2 | 19 ± 2.7* | 61 ± 8.5† | 58 ± 9.1† |
| Luminal area | 19 ± 5.2 | 59 ± 5.3* | 33 ± 8.6‡ | 29 ± 6.3§ |
| % stenosis | 78 ± 5.4 | 25 ± 3.9* | 66 ± 7.0† | 64 ± 7.6† |
| . | SR-BI+/+ bone marrow . | SR-BI−/− bone marrow . | ||
|---|---|---|---|---|
| Controls . | AdA-I . | Controls . | AdA-I . | |
| No. of mice | 18 | 21 | 14 | 17 |
| Area within the external elastic lamina | 150 ± 9.9 | 140 ± 8.1 | 140 ± 10 | 150 ± 8.5 |
| Area within the internal elastic lamina | 89 ± 7.2 | 78 ± 4.7 | 94 ± 9.2 | 87 ± 4.9 |
| Medial area | 66 ± 4.0 | 62 ± 4.6 | 55 ± 4.7 | 59 ± 5.0 |
| Intimal area | 70 ± 8.2 | 19 ± 2.7* | 61 ± 8.5† | 58 ± 9.1† |
| Luminal area | 19 ± 5.2 | 59 ± 5.3* | 33 ± 8.6‡ | 29 ± 6.3§ |
| % stenosis | 78 ± 5.4 | 25 ± 3.9* | 66 ± 7.0† | 64 ± 7.6† |
C57BL/6 mice were transplanted with SR-BI+/+ or SR-BI−/− bone marrow and injected 14 days before transplantation with the control vector Adnull or saline (Controls) or a human apo A-I–expressing adenoviral vector (AdA-I). Morphometric data are expressed in 103 μm2 and represent mean plus or minus SEM. The percentage stenosis is defined as the intimal area divided by the area within the internal elastical lamina multiplied by 100 (%).
P < .001 vs SR-BI+/+ bone marrow controls.
P < .001 vs SR-BI+/+ bone marrow AdA-I.
P < .05 vs SR-BI+/+ bone marrow AdA-I.
P < .01 vs SR-BI+/+ bone marrow AdA-I.