Table 1 Total cholesterol, non-HDL... | American Society of Hematology

Table 1

Total cholesterol, non-HDL cholesterol, and HDL cholesterol plasma levels at baseline and at different time points after gene transfer with 5 × 10¹⁰ particles of AdA-I or Adnull in C57BL/6 mice transplanted with SR-BI^+/+ or SR-BI^−/− bone marrow

	SR-BI^+/+ bone marrow			SR-BI^−/− bone marrow
	Baseline	Day 14	Day 35	Baseline	Day 14	Day 35
AdA-I
Total cholesterol	71 ± 2.0	140 ± 3.1*	130 ± 4.0*	70 ± 2.7	140 ± 3.4*	130 ± 4.9*
Non-HDL cholesterol	12 ± 1.4	26 ± 0.90*	22 ± 1.2*	12 ± 1.8	27 ± 1.0*	23 ± 1.4*
HDL cholesterol	59 ± 0.93	120 ± 2.2*	100 ± 3.0*	58 ± 1.1	120 ± 2.4*	110 ± 3.6*
Adnull
Total cholesterol	74 ± 1.9	72 ± 3.0	71 ± 2.3	71 ± 2.6	73 ± 2.5	71 ± 2.7
Non-HDL cholesterol	14 ± 1.4	13 ± 2.0	12 ± 1.5	13 ± 1.6	14 ± 1.7	12 ± 1.9
HDL cholesterol	60 ± 0.79	58 ± 1.1	59 ± 0.97	58 ± 1.1	60 ± 0.83	59 ± 1.3

	SR-BI^+/+ bone marrow			SR-BI^−/− bone marrow
	Baseline	Day 14	Day 35	Baseline	Day 14	Day 35
AdA-I
Total cholesterol	71 ± 2.0	140 ± 3.1*	130 ± 4.0*	70 ± 2.7	140 ± 3.4*	130 ± 4.9*
Non-HDL cholesterol	12 ± 1.4	26 ± 0.90*	22 ± 1.2*	12 ± 1.8	27 ± 1.0*	23 ± 1.4*
HDL cholesterol	59 ± 0.93	120 ± 2.2*	100 ± 3.0*	58 ± 1.1	120 ± 2.4*	110 ± 3.6*
Adnull
Total cholesterol	74 ± 1.9	72 ± 3.0	71 ± 2.3	71 ± 2.6	73 ± 2.5	71 ± 2.7
Non-HDL cholesterol	14 ± 1.4	13 ± 2.0	12 ± 1.5	13 ± 1.6	14 ± 1.7	12 ± 1.9
HDL cholesterol	60 ± 0.79	58 ± 1.1	59 ± 0.97	58 ± 1.1	60 ± 0.83	59 ± 1.3

Non-HDL and HDL particles were separated by fast performance liquid chromatography gel filtration. Data are expressed in milligrams per deciliter and represent mean plus or minus SEM (n = 10 mice for each experimental condition).

P < .001 for comparison of different time points after transfer with baseline values.

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