Table 3

P for association of each SNP with VT

SNP*P† for association with VT
Original kindred
Extended kindred
AllPC-deficientNormal PCAllPC-deficientNormal PC
rs17564430 .0376 .00985 .489 .332 .278 .467 
rs10891802 .000223 .0000215 .284 .00829 .00643 .342 
rs11215397 .000299 .0000614 .345 .0167 .0148 .355 
rs3802858 .00100 .0000514 .300 .0235 .0110 .291 
rs6589488 .000215 .0000141 .499 .00000720 .00000100 .444 
rs10790068 .000727 .0000352 .580 .000138 .0000153 .581 
rs7927241 .000465 .000726 .202 .0767 .0710 .326 
rs11215474 .000465 .000726 .202 .0767 .0710 .326 
SNP*P† for association with VT
Original kindred
Extended kindred
AllPC-deficientNormal PCAllPC-deficientNormal PC
rs17564430 .0376 .00985 .489 .332 .278 .467 
rs10891802 .000223 .0000215 .284 .00829 .00643 .342 
rs11215397 .000299 .0000614 .345 .0167 .0148 .355 
rs3802858 .00100 .0000514 .300 .0235 .0110 .291 
rs6589488 .000215 .0000141 .499 .00000720 .00000100 .444 
rs10790068 .000727 .0000352 .580 .000138 .0000153 .581 
rs7927241 .000465 .000726 .202 .0767 .0710 .326 
rs11215474 .000465 .000726 .202 .0767 .0710 .326 

PC indicates protein C; SNP, single nucleotide polymorphism; and VT, venous thrombosis.

*

n = 62 for rs7927241 and rs11215474; n = 450-453 for the other SNPs in the extended kindred.

†

From a mixture χ2 statistic with 2 df, testing both dominant and recessive effects.

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