Table 1 Clinical data of patients with... | American Society of Hematology

Table 1

Clinical data of patients with IGF-1R^absent and IGF-1R^present MMCs and of patients with IL-6R^low and IL-6R^high MMCs

Category	IGF-1R, % of patients in each group		IL-6R, % of patients in each group
Category	IGF-1R^absent (n = 118), %	IGF-1R^present (n = 53), %	IL-6R^low (n = 85), %	IL-6R^high (n = 85), %
Age ≥ 65 y	26	21	26	24
Kappa light chain	64	64	63	65
Lambda light chain	33	34	36	32
Nonsecreting	3	2	1	3
B2M ≤ 3.5 mg/mL	60	58	63	56
B2M > 5.5 mg/mL	17	17	19	15
IgA subtype	20*	33*	15*	33*
LDH ≥ 240 IU/L	26*	12*	24	19
Albumin < 35 g/L	37	36	44	31
Hemoglobin < 10 g/dL	31	32	29	34
C-reactive protein ≥ 5 mg/L	40	40	43	38
Bone lesions
0, normal bone structure	18	27	21	22
1, osteopenia/osteoporosis	28	25	22	33
2, osteolyse (1–3)	8	10	9	9
3, major structural damage (>3)	46	38	48	36

Category	IGF-1R, % of patients in each group		IL-6R, % of patients in each group
Category	IGF-1R^absent (n = 118), %	IGF-1R^present (n = 53), %	IL-6R^low (n = 85), %	IL-6R^high (n = 85), %
Age ≥ 65 y	26	21	26	24
Kappa light chain	64	64	63	65
Lambda light chain	33	34	36	32
Nonsecreting	3	2	1	3
B2M ≤ 3.5 mg/mL	60	58	63	56
B2M > 5.5 mg/mL	17	17	19	15
IgA subtype	20*	33*	15*	33*
LDH ≥ 240 IU/L	26*	12*	24	19
Albumin < 35 g/L	37	36	44	31
Hemoglobin < 10 g/dL	31	32	29	34
C-reactive protein ≥ 5 mg/L	40	40	43	38
Bone lesions
0, normal bone structure	18	27	21	22
1, osteopenia/osteoporosis	28	25	22	33
2, osteolyse (1–3)	8	10	9	9
3, major structural damage (>3)	46	38	48	36

The 171 previously untreated patients with MM were treated at the university hospitals of Heidelberg or Montpellier. Patients were separated into 2 groups: patients with IGF-1R^absent MMCs and patients with IGF-1R^present MMCs or patients with IL-6R^low MMCs and IL6R^high MMCs, as assayed with Affymetrix microarrays. Data are the percentages of patients within these 2 groups with the indicated clinical or biologic parameters.

B2M indicates β2-microglobulin; and LDH, lactate dehydrogenase.

The percentages were different with a χ² test (P ≤ .05).

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