Odds ratios (95% confidence intervals) of venous thromboembolism in relation to quintiles of factor IX and XI: LITE
| . | Odds ratio (95% CI) of VTE by quintile . | ||||
|---|---|---|---|---|---|
| 1 . | 2 . | 3 . | 4 . | 5 . | |
| Factor IX, % | < 118 | 118-133 | 133-147 | 147-167 | ≥ 167 |
| Overall VTE | |||||
| Model 1 | 1 (reference) | 1.0 (0.7-1.4) | 1.0 (0.7-1.4) | 1.3 (0.9-1.9) | 1.4 (1.0-2.0) |
| Model 2 | 1 (reference) | 0.9 (0.6-1.3) | 0.9 (0.6-1.3) | 1.1 (0.8-1.6) | 1.1 (0.7-1.6) |
| Idiopathic VTE | |||||
| Model 1 | 1 (reference) | 0.8 (0.5-1.4) | 0.9 (0.5-1.5) | 1.3 (0.8-2.1) | 1.3 (0.8-2.1) |
| Model 2 | 1 (reference) | 0.8 (0.5-1.4) | 0.8 (0.5-1.4) | 1.1 (0.7-1.8) | 1.0 (0.6-1.7) |
| Secondary VTE | |||||
| Model 1 | 1 (reference) | 1.1 (0.7-1.8) | 1.1 (0.7-1.7) | 1.4 (0.9-2.1) | 1.5 (1.0-2.4) |
| Model 2 | 1 (reference) | 1.0 (0.6-1.6) | 1.0 (0.6-1.5) | 1.2 (0.7-1.8) | 1.1 (0.7-1.8) |
| ARIC | |||||
| Model 1 | 1 (reference) | 1.0 (0.7-1.6) | 0.8 (0.5-1.2) | 1.6 (1.0-2.4) | 1.5 (1.0-2.4) |
| Model 2 | 1 (reference) | 0.9 (0.6-1.4) | 0.7 (0.4-1.2) | 1.3 (0.9-2.1) | 1.2 (0.7-1.9) |
| CHS | |||||
| Model 1 | 1 (reference) | 0.9 (0.5-1.8) | 1.4 (0.7-2.6) | 1.1 (0.6-2.0) | 1.3 (0.7-2.4) |
| Model 2 | 1 (reference) | 1.0 (0.5-1.9) | 1.3 (0.7-2.4) | 0.9 (0.5-1.7) | 1.0 (0.5-1.8) |
| Factor XI, % | < 104 | 104-120 | 120-134 | 134-157 | ≥ 157 |
| Overall VTE | |||||
| Model 1 | 1 (reference) | 1.3 (0.9-1.9) | 1.3 (0.9-1.9) | 1.4 (1.0-2.1) | 2.0 (1.4-2.9) |
| Model 2 | 1 (reference) | 1.3 (0.9-1.9) | 1.2 (0.8-1.8) | 1.4 (1.0-2.0) | 1.8 (1.3-2.7) |
| Idiopathic VTE | |||||
| Model 1 | 1 (reference) | 1.2 (0.7-2.1) | 1.3 (0.8-2.2) | 1.5 (0.9-2.5) | 2.2 (1.3-3.6) |
| Model 2 | 1 (reference) | 1.2 (0.7-2.1) | 1.3 (0.8-2.2) | 1.4 (0.8-2.5) | 2.0 (1.2-3.4) |
| Secondary VTE | |||||
| Model 1 | 1 (reference) | 1.4 (0.9-2.2) | 1.3 (0.8-2.0) | 1.4 (0.9-2.2) | 2.0 (1.2-3.1) |
| Model 2 | 1 (reference) | 1.3 (0.8-2.1) | 1.2 (0.8-1.9) | 1.4 (0.9-2.2) | 1.7 (1.1-2.7) |
| ARIC | |||||
| Model 1 | 1 (reference) | 1.5 (0.9-2.4) | 1.1 (0.7-1.9) | 1.4 (0.8-2.2) | 1.9 (1.2-3.0) |
| Model 2 | 1 (reference) | 1.4 (0.8-2.3) | 1.1 (0.6-1.8) | 1.3 (0.8-2.1) | 1.7 (1.0-2.7) |
| CHS | |||||
| Model 1 | 1 (reference) | 1.2 (0.7-2.0) | 1.5 (0.9-2.7) | 1.6 (0.9-2.8) | 2.3 (1.3-4.2) |
| Model 2 | 1 (reference) | 1.2 (0.7-2.1) | 1.5 (0.9-2.7) | 1.6 (0.8-2.8) | 2.2 (1.2-4.0) |
| . | Odds ratio (95% CI) of VTE by quintile . | ||||
|---|---|---|---|---|---|
| 1 . | 2 . | 3 . | 4 . | 5 . | |
| Factor IX, % | < 118 | 118-133 | 133-147 | 147-167 | ≥ 167 |
| Overall VTE | |||||
| Model 1 | 1 (reference) | 1.0 (0.7-1.4) | 1.0 (0.7-1.4) | 1.3 (0.9-1.9) | 1.4 (1.0-2.0) |
| Model 2 | 1 (reference) | 0.9 (0.6-1.3) | 0.9 (0.6-1.3) | 1.1 (0.8-1.6) | 1.1 (0.7-1.6) |
| Idiopathic VTE | |||||
| Model 1 | 1 (reference) | 0.8 (0.5-1.4) | 0.9 (0.5-1.5) | 1.3 (0.8-2.1) | 1.3 (0.8-2.1) |
| Model 2 | 1 (reference) | 0.8 (0.5-1.4) | 0.8 (0.5-1.4) | 1.1 (0.7-1.8) | 1.0 (0.6-1.7) |
| Secondary VTE | |||||
| Model 1 | 1 (reference) | 1.1 (0.7-1.8) | 1.1 (0.7-1.7) | 1.4 (0.9-2.1) | 1.5 (1.0-2.4) |
| Model 2 | 1 (reference) | 1.0 (0.6-1.6) | 1.0 (0.6-1.5) | 1.2 (0.7-1.8) | 1.1 (0.7-1.8) |
| ARIC | |||||
| Model 1 | 1 (reference) | 1.0 (0.7-1.6) | 0.8 (0.5-1.2) | 1.6 (1.0-2.4) | 1.5 (1.0-2.4) |
| Model 2 | 1 (reference) | 0.9 (0.6-1.4) | 0.7 (0.4-1.2) | 1.3 (0.9-2.1) | 1.2 (0.7-1.9) |
| CHS | |||||
| Model 1 | 1 (reference) | 0.9 (0.5-1.8) | 1.4 (0.7-2.6) | 1.1 (0.6-2.0) | 1.3 (0.7-2.4) |
| Model 2 | 1 (reference) | 1.0 (0.5-1.9) | 1.3 (0.7-2.4) | 0.9 (0.5-1.7) | 1.0 (0.5-1.8) |
| Factor XI, % | < 104 | 104-120 | 120-134 | 134-157 | ≥ 157 |
| Overall VTE | |||||
| Model 1 | 1 (reference) | 1.3 (0.9-1.9) | 1.3 (0.9-1.9) | 1.4 (1.0-2.1) | 2.0 (1.4-2.9) |
| Model 2 | 1 (reference) | 1.3 (0.9-1.9) | 1.2 (0.8-1.8) | 1.4 (1.0-2.0) | 1.8 (1.3-2.7) |
| Idiopathic VTE | |||||
| Model 1 | 1 (reference) | 1.2 (0.7-2.1) | 1.3 (0.8-2.2) | 1.5 (0.9-2.5) | 2.2 (1.3-3.6) |
| Model 2 | 1 (reference) | 1.2 (0.7-2.1) | 1.3 (0.8-2.2) | 1.4 (0.8-2.5) | 2.0 (1.2-3.4) |
| Secondary VTE | |||||
| Model 1 | 1 (reference) | 1.4 (0.9-2.2) | 1.3 (0.8-2.0) | 1.4 (0.9-2.2) | 2.0 (1.2-3.1) |
| Model 2 | 1 (reference) | 1.3 (0.8-2.1) | 1.2 (0.8-1.9) | 1.4 (0.9-2.2) | 1.7 (1.1-2.7) |
| ARIC | |||||
| Model 1 | 1 (reference) | 1.5 (0.9-2.4) | 1.1 (0.7-1.9) | 1.4 (0.8-2.2) | 1.9 (1.2-3.0) |
| Model 2 | 1 (reference) | 1.4 (0.8-2.3) | 1.1 (0.6-1.8) | 1.3 (0.8-2.1) | 1.7 (1.0-2.7) |
| CHS | |||||
| Model 1 | 1 (reference) | 1.2 (0.7-2.0) | 1.5 (0.9-2.7) | 1.6 (0.9-2.8) | 2.3 (1.3-4.2) |
| Model 2 | 1 (reference) | 1.2 (0.7-2.1) | 1.5 (0.9-2.7) | 1.6 (0.8-2.8) | 2.2 (1.2-4.0) |
Model 1 adjusted for age, sex, race, and study. Model 2 adjusted additionally for BMI and diabetes.