Clinical characteristics of the patients
| . | Patient 1 . | Patient 2 . | Patient 3 . |
|---|---|---|---|
| Age, y | |||
| At the onset of symptoms | 33 | 28 | 37 |
| At the time of LT | 36 | 39 | 42 |
| Sex | Female | Female | Female |
| Smoking status (pack-years) | Former smoker (1) | Nonsmoker | Former smoker (8) |
| Environment or occupational exposure | Not found | Not found | Not found |
| Adenopathies | (−) | (−) | (−) |
| Splenomegaly | (−) | (−) | (−) |
| Hepatomegaly | (−) | (−) | (−) |
| Viral status, serology | |||
| HCV infection | (−) | (−) | (−) |
| HIV infection | (−) | (−) | (−) |
| Monoclonal IG before LT* | |||
| Serum | Free κ light chain | (−) | (−) |
| Urine | (−) | ND | ND |
| Serum IgG, IgA, IgM levels | Normal | Normal | Normal |
| Bone marrow plasmocytes, % | < 5 | < 5 | < 5 |
| Renal function (serum creatinine level, μmol/L) | Normal (50) | Normal (55) | Normal (100) |
| Proteinuria, mg/d | 70 | 60 | 200 |
| Liver function tests | Normal | Normal | Normal |
| Heart function† | Normal | Normal | Normal |
| Extrapulmonary deposits | |||
| Bone marrow | (−) | (−) | (−) |
| Salivary glands | + | (−) | + |
| Skin | ¤ | (−) | ¤ |
| Duodenum | ¤ | (−) | ¤ |
| Rectum | ¤ | (−) | ¤ |
| Kidney | ¤ | ¤ | (−) |
| Autologous blood stem cell transplantation before LT | No | Yes‡ | No |
| Follow up, mo | 39 | 69 | 33 |
| Monoclonal IG after LT* | |||
| Serum | (−) | (−) | (−) |
| Urine | (−) | (−) | (−) |
| Recurrence of the disease | No | No | No |
| . | Patient 1 . | Patient 2 . | Patient 3 . |
|---|---|---|---|
| Age, y | |||
| At the onset of symptoms | 33 | 28 | 37 |
| At the time of LT | 36 | 39 | 42 |
| Sex | Female | Female | Female |
| Smoking status (pack-years) | Former smoker (1) | Nonsmoker | Former smoker (8) |
| Environment or occupational exposure | Not found | Not found | Not found |
| Adenopathies | (−) | (−) | (−) |
| Splenomegaly | (−) | (−) | (−) |
| Hepatomegaly | (−) | (−) | (−) |
| Viral status, serology | |||
| HCV infection | (−) | (−) | (−) |
| HIV infection | (−) | (−) | (−) |
| Monoclonal IG before LT* | |||
| Serum | Free κ light chain | (−) | (−) |
| Urine | (−) | ND | ND |
| Serum IgG, IgA, IgM levels | Normal | Normal | Normal |
| Bone marrow plasmocytes, % | < 5 | < 5 | < 5 |
| Renal function (serum creatinine level, μmol/L) | Normal (50) | Normal (55) | Normal (100) |
| Proteinuria, mg/d | 70 | 60 | 200 |
| Liver function tests | Normal | Normal | Normal |
| Heart function† | Normal | Normal | Normal |
| Extrapulmonary deposits | |||
| Bone marrow | (−) | (−) | (−) |
| Salivary glands | + | (−) | + |
| Skin | ¤ | (−) | ¤ |
| Duodenum | ¤ | (−) | ¤ |
| Rectum | ¤ | (−) | ¤ |
| Kidney | ¤ | ¤ | (−) |
| Autologous blood stem cell transplantation before LT | No | Yes‡ | No |
| Follow up, mo | 39 | 69 | 33 |
| Monoclonal IG after LT* | |||
| Serum | (−) | (−) | (−) |
| Urine | (−) | (−) | (−) |
| Recurrence of the disease | No | No | No |
LT indicates lung transplantation; HCV, hepatitis C virus; HIV, human immunodeficiency virus; (−), absent; ND; not done; +, present; and ¤, no biopsy performed.
Protein electrophoresis and immunofixation.
Evaluated by echocardiography and right cardiac catheterization.
Without improvement or stabilization.