Apoptosis-related genes significantly up-regulated in KG1a cells in coculture with stroma
| Gene symbols . | Gene description . | Log . | P . |
|---|---|---|---|
| LTBR | Lymphotoxin beta receptor (TNFR SF, member 3). This receptor is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. | 66.80 | < .001 |
| TNFRSF11B | TNFR SF, member 11b (osteoprotegerin). This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. | 43.25 | < .001 |
| PYCARD | PYD and CARD domain containing. The PYD and CARD domains are members of the 6-helix bundle, death-domain–fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspases. | 7.79 | < .001 |
| CD40 | CD40 molecule, TNFR SF, member 5. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses, including T cell–dependent immunoglobulin class switching, memory B-cell development, and germinal center formation. | 6.57 | .002 |
| P53 | Tumor protein p53 gene encodes the tumor suppressor p53, which responds to diverse cellular stresses to regulate target genes that induce cell-cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. | 2.85 | .027 |
| CD70 | The protein encoded by this gene is a cytokine that belongs to the TNF ligand family. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T-cell activation. | 2.42 | .006 |
| TNFRSF10B | TNFR SF, member 10b. The protein encoded by this gene contains an intracellular death domain. | 2.31 | .005 |
| Gene symbols . | Gene description . | Log . | P . |
|---|---|---|---|
| LTBR | Lymphotoxin beta receptor (TNFR SF, member 3). This receptor is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. | 66.80 | < .001 |
| TNFRSF11B | TNFR SF, member 11b (osteoprotegerin). This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. | 43.25 | < .001 |
| PYCARD | PYD and CARD domain containing. The PYD and CARD domains are members of the 6-helix bundle, death-domain–fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspases. | 7.79 | < .001 |
| CD40 | CD40 molecule, TNFR SF, member 5. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses, including T cell–dependent immunoglobulin class switching, memory B-cell development, and germinal center formation. | 6.57 | .002 |
| P53 | Tumor protein p53 gene encodes the tumor suppressor p53, which responds to diverse cellular stresses to regulate target genes that induce cell-cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. | 2.85 | .027 |
| CD70 | The protein encoded by this gene is a cytokine that belongs to the TNF ligand family. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T-cell activation. | 2.42 | .006 |
| TNFRSF10B | TNFR SF, member 10b. The protein encoded by this gene contains an intracellular death domain. | 2.31 | .005 |
The procedure for quantifying expression of these genes is explained in ″Methods.″