Table 2 Changes in plasma cytokines with... | American Society of Hematology

Table 2

Changes in plasma cytokines with time

Cytokine	Time after start of rituximab therapy, mo
Cytokine	1 (n = 16)	3 (n = 16)	6 (n = 15)	12 (n = 8)
IL-1β
Median change, pg/mL	0	0	0	−4
P	>.999	.94	.75	.23
IL-2
Median change, pg/mL	0	0	0	−2
P	.28	.72	.14	.14
IL-4
Median change, pg/mL	0	1	2	26
P	.1	.59	.88	.35
IL-5
Median change, pg/mL	−1	−2	−6	−7.5
P	.14	.39	0	.04*
IL-6
Median change, pg/mL	−2.5	−11	−8	−9
P	.006	.001*	.15	.04*
IL-8
Median change, pg/mL	−27.5	−18	27 238	21.5
P	.16	.26	.33	.89
IL-10
Median change, pg/mL	−113.5	−110	−130	−145
P	.01*	.06	.06	.02*
IL-12
Median change, pg/mL	8.5	0	−17	−43
P	.42	.6	.36	.06*
IL-13
Median change, pg/mL	0	0	0	0
P	.59	.08	.96	.47
IL-15
Median change, pg/mL	0	0	0	0
P	>.999	.09	.1	.11
IL-17
Median change, pg/mL	0	0	0	−3
P	.73	.41	.03*	.28
GM-CSF
Median change, pg/mL	0	0	0	−7.5
P	.26	.95	.76	.06
TNF-α
Median change, pg/mL	0	0	0	0
P	.32	.89	.18	.11
IFN-α
Median change, pg/mL	0	0	0	0
P	.41	.03*	.27	.27
IFN-γ
Median change, pg/mL	0	0	0	0
P	.72	.88	.66	.46

Cytokine	Time after start of rituximab therapy, mo
Cytokine	1 (n = 16)	3 (n = 16)	6 (n = 15)	12 (n = 8)
IL-1β
Median change, pg/mL	0	0	0	−4
P	>.999	.94	.75	.23
IL-2
Median change, pg/mL	0	0	0	−2
P	.28	.72	.14	.14
IL-4
Median change, pg/mL	0	1	2	26
P	.1	.59	.88	.35
IL-5
Median change, pg/mL	−1	−2	−6	−7.5
P	.14	.39	0	.04*
IL-6
Median change, pg/mL	−2.5	−11	−8	−9
P	.006	.001*	.15	.04*
IL-8
Median change, pg/mL	−27.5	−18	27 238	21.5
P	.16	.26	.33	.89
IL-10
Median change, pg/mL	−113.5	−110	−130	−145
P	.01*	.06	.06	.02*
IL-12
Median change, pg/mL	8.5	0	−17	−43
P	.42	.6	.36	.06*
IL-13
Median change, pg/mL	0	0	0	0
P	.59	.08	.96	.47
IL-15
Median change, pg/mL	0	0	0	0
P	>.999	.09	.1	.11
IL-17
Median change, pg/mL	0	0	0	−3
P	.73	.41	.03*	.28
GM-CSF
Median change, pg/mL	0	0	0	−7.5
P	.26	.95	.76	.06
TNF-α
Median change, pg/mL	0	0	0	0
P	.32	.89	.18	.11
IFN-α
Median change, pg/mL	0	0	0	0
P	.41	.03*	.27	.27
IFN-γ
Median change, pg/mL	0	0	0	0
P	.72	.88	.66	.46

Median change indicates median change of value compared with value before rituximab therapy for each time point.

Significant, P < .05.