Relationship between additional chromosome abnormalities, BCR breakpoint, and outcome
| . | Death . | Any event . | Relapse . | Death in CR . | ||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) . | P . | OR (95% CI) . | P . | OR (95% CI) . | P . | OR (95% CI) . | P . | |
| BCR breakpoint, minor vs major | 1.22 (0.82-1.83) | > .1 | 1.31 (0.88-1.96) | > .1 | 1.78 (1.03-3.08) | .05* | 0.77 (0.31-1.94) | > .1 |
| Extra Ph chromosome [+der(22)] | 0.82 (0.58-1.16) | > .1 | 0.77 (0.55-1.07) | > .1 | 0.64 (0.42-0.99) | .04* | 1.38 (0.70-2.72) | > .1 |
| HeH | 0.72 (0.47-1.08) | > .1 | 0.69 (0.46-1.03) | .06 | 0.55 (0.33-0.91) | .01* | 1.29 (0.58-2.85) | > .1 |
| −7 | 1.11 (0.72-1.70) | > .1 | 1.10 (0.72-1.66) | > .1 | 1.06 (0.60-1.89) | > .1 | 1.37 (0.56-3.38) | > .1 |
| +8 | 0.72 (0.46-1.12) | > .1 | 0.72 (0.47-1.11) | > .1 | 0.76 (0.44-1.34) | > .1 | 0.69 (0.29-1.67) | > .1 |
| del(9p) | 0.92 (0.58-1.45) | > .1 | 1.40 (0.84-2.34) | > .1 | 2.45 (1.27-4.72) | .01* | 0.59 (0.21-1.71) | > .1 |
| . | Death . | Any event . | Relapse . | Death in CR . | ||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) . | P . | OR (95% CI) . | P . | OR (95% CI) . | P . | OR (95% CI) . | P . | |
| BCR breakpoint, minor vs major | 1.22 (0.82-1.83) | > .1 | 1.31 (0.88-1.96) | > .1 | 1.78 (1.03-3.08) | .05* | 0.77 (0.31-1.94) | > .1 |
| Extra Ph chromosome [+der(22)] | 0.82 (0.58-1.16) | > .1 | 0.77 (0.55-1.07) | > .1 | 0.64 (0.42-0.99) | .04* | 1.38 (0.70-2.72) | > .1 |
| HeH | 0.72 (0.47-1.08) | > .1 | 0.69 (0.46-1.03) | .06 | 0.55 (0.33-0.91) | .01* | 1.29 (0.58-2.85) | > .1 |
| −7 | 1.11 (0.72-1.70) | > .1 | 1.10 (0.72-1.66) | > .1 | 1.06 (0.60-1.89) | > .1 | 1.37 (0.56-3.38) | > .1 |
| +8 | 0.72 (0.46-1.12) | > .1 | 0.72 (0.47-1.11) | > .1 | 0.76 (0.44-1.34) | > .1 | 0.69 (0.29-1.67) | > .1 |
| del(9p) | 0.92 (0.58-1.45) | > .1 | 1.40 (0.84-2.34) | > .1 | 2.45 (1.27-4.72) | .01* | 0.59 (0.21-1.71) | > .1 |
An OR greater than 1 indicates an increased risk of the event observed in relationship to the presence of the particular chromosome abnormality studied. In the case of major BCR breakpoint, the comparator is minor breakpoint.
OR indicates odds ratio; and CI, confidence interval.
Statistically significant P values.