Percentages of intermediate- and late-differentiated CD8+ T cells based on the expression of CD28 and CD27 in HTLV-1 Tax– and CMV pp65–specific CD8+ T cells of patients with HAM/TSP and HVCs
| . | Tax-specific . | CMV-specific . | ||
|---|---|---|---|---|
| Intermediate . | Late . | Intermediate . | Late . | |
| HAM/TSP | 38.1 ± 5.2 (n = 16) | 61.0 ± 5.3 (n=16) | 17.7 ± 5.8 (n = 12) | 81.9 ± 5.8 (n = 12) |
| HVCs | 66.3 ± 3.8 (n = 17) | 32.7 ± 3.6 (n=17) | 10.3 ± 4.0 (n = 8) | 89.0 ± 2.4 (n = 8) |
| All | 52.6 ± 4.0 (n = 33) | 46.4 ± 4.0 (n=33) | 14.8 ± 3.6 (n = 20) | 84.7 ± 3.6 (n = 20) |
| P* | < .001 | < .001 | .88 | .88 |
| . | Tax-specific . | CMV-specific . | ||
|---|---|---|---|---|
| Intermediate . | Late . | Intermediate . | Late . | |
| HAM/TSP | 38.1 ± 5.2 (n = 16) | 61.0 ± 5.3 (n=16) | 17.7 ± 5.8 (n = 12) | 81.9 ± 5.8 (n = 12) |
| HVCs | 66.3 ± 3.8 (n = 17) | 32.7 ± 3.6 (n=17) | 10.3 ± 4.0 (n = 8) | 89.0 ± 2.4 (n = 8) |
| All | 52.6 ± 4.0 (n = 33) | 46.4 ± 4.0 (n=33) | 14.8 ± 3.6 (n = 20) | 84.7 ± 3.6 (n = 20) |
| P* | < .001 | < .001 | .88 | .88 |
| . | Tax-specific . | PVL . | P * . | |
|---|---|---|---|---|
| Intermediate . | Late . | |||
| PVL-matched, HAM/TSP | 39.2 ± 7.6 (n = 9) | 56.6 ± 7.9 (n = 9) | 470.3 ± 75.0 | .11 |
| PVL-matched, HVCs | 68.2 ± 4.9 (n = 10) | 31.4 ± 4.9 (n = 10) | 303.5 ± 70.0 | |
| PVL-matched, all | 54.4 ± 5.5 (n = 19) | 44.8 ± 4.9 (n = 19) | 382.5 ± 50.4 | |
| P* | .004 | .006 | ||
| . | Tax-specific . | PVL . | P * . | |
|---|---|---|---|---|
| Intermediate . | Late . | |||
| PVL-matched, HAM/TSP | 39.2 ± 7.6 (n = 9) | 56.6 ± 7.9 (n = 9) | 470.3 ± 75.0 | .11 |
| PVL-matched, HVCs | 68.2 ± 4.9 (n = 10) | 31.4 ± 4.9 (n = 10) | 303.5 ± 70.0 | |
| PVL-matched, all | 54.4 ± 5.5 (n = 19) | 44.8 ± 4.9 (n = 19) | 382.5 ± 50.4 | |
| P* | .004 | .006 | ||
Values represent the means plus minus SE.
P values between HAM-HVCs were calculated by Mann-Whitney U test. PVL: HTLV-1 tax copy number per 104 PBMCs.