Childhood leukemia cases sequenced for exon 14 JAK2 mutations
| Disease . | Total, n . | JAK2R683G, n . | JAK2R683S, n . | JAK2 WT, n . |
|---|---|---|---|---|
| DS-ALL* | 42 | 10 | 2 | 30 |
| BCP-ALL (HeH) | 41 (23) | 0 | 0 | 41 (23) |
| DS-AMKL | 13 | 0 | 0 | 13 |
| Disease . | Total, n . | JAK2R683G, n . | JAK2R683S, n . | JAK2 WT, n . |
|---|---|---|---|---|
| DS-ALL* | 42 | 10 | 2 | 30 |
| BCP-ALL (HeH) | 41 (23) | 0 | 0 | 41 (23) |
| DS-AMKL | 13 | 0 | 0 | 13 |
DS-ALL indicates Down syndrome acute lymphoblastic leukemia; HeH, high hyperdiploidy; BCP-ALL, B-cell precursor/common ALL (cALL); DS-AMKL, Down syndrome acute megakaryoblastic leukemia; and WT, wild type.
GATA1 mutation status unknown; 4 cases with matched remission DNA for sequencing, 7 with matched remission DNA for SNP arrays (see Tables S1,S3 for details).