Latencies of primary and secondary leukemias
| Leukemic cells . | Latency of primary AML, d . | Latency of secondary AML . | Latency of secondary AML after culture . |
|---|---|---|---|
| cME3a | 80 | 21.4 ± 0.6 (n = 5) | ND |
| ME4a | 76 | 26.2 ± 1.1 (n = 5) | 17.8 ± 9.2 (n = 5)* |
| ME4b | 83 | 26.8 ± 0.5 (n = 5) | ND |
| ME4c | 75 | 22.4 ± 2.5 (n = 5) | ND |
| ME5a | 83 | 16.6 ± 2.2 (n = 10) | 22.0 ± 9.5 (n = 10)* |
| ME7a | 81 | 34.2 ± 3.3 (n = 5) | 14.2 ± 3.3 (n = 5)* |
| ME7b | 89 | 30.5 ± 2.4 (n = 4) | ND |
| ME7c | 83 | 37.0 ± 7.4 (n = 5) | ND |
| Leukemic cells . | Latency of primary AML, d . | Latency of secondary AML . | Latency of secondary AML after culture . |
|---|---|---|---|
| cME3a | 80 | 21.4 ± 0.6 (n = 5) | ND |
| ME4a | 76 | 26.2 ± 1.1 (n = 5) | 17.8 ± 9.2 (n = 5)* |
| ME4b | 83 | 26.8 ± 0.5 (n = 5) | ND |
| ME4c | 75 | 22.4 ± 2.5 (n = 5) | ND |
| ME5a | 83 | 16.6 ± 2.2 (n = 10) | 22.0 ± 9.5 (n = 10)* |
| ME7a | 81 | 34.2 ± 3.3 (n = 5) | 14.2 ± 3.3 (n = 5)* |
| ME7b | 89 | 30.5 ± 2.4 (n = 4) | ND |
| ME7c | 83 | 37.0 ± 7.4 (n = 5) | ND |
Values represent the latency of the primary leukemias and the mean latency and SD (numbers of mice per group are indicated) of secondary leukemias resulting from transplantation of the primary leukemias ex vivo or after culture for 1 month in vitro.
ND indicates not determined.
In vitro culture of leukemic cells caused a small but significant increase in ME5a latency (P = .038, Mantel-Haenszel log-rank test), had no effect on ME4a latency (P = .269), and reduced the latency of ME7a (P = .002).