Clinical and laboratory features at diagnosis
| . | 800-mg arm (n = 108) . | 400-mg arm (n = 108) . |
|---|---|---|
| Sex, male/female, no. (%) | 60/48 (55/45) | 62/46 (57/43) |
| Median age, y (range) | 51 (18-84) | 51 (18-81) |
| Performance status (ECOG) 1 or less, n (%) | 103 (95) | 106 (98) |
| Median spleen, cm (range)* | 10 (0-38) | 10 (0-31) |
| Median Hb, g/L (range) | 107 (68-145) | 112 (53-155) |
| Median platelet count, × 109/L (range) | 520 (130-2586) | 480 (80-4553) |
| Median WBC count, × 109/L (range) | 148 (14-500) | 160 (19-478) |
| Median blood myeloblasts, % (range) | 5 (0-11) | 5 (0-13) |
| Median blood eosinophils, % (range) | 3 (0-12) | 2 (0-17) |
| Median blood basophils, % (range) | 4 (0-19) | 3 (0-15) |
| Additional chromosome abnormalities, no. (%) | 3 (3) | 5 (5) |
| Median Sokal score (range) | 1.57 (1.22-7.61) | 1.57 (1.21-8.25) |
| High risk by Hasford score, no. (%) | 47 (43) | 43 (40) |
| . | 800-mg arm (n = 108) . | 400-mg arm (n = 108) . |
|---|---|---|
| Sex, male/female, no. (%) | 60/48 (55/45) | 62/46 (57/43) |
| Median age, y (range) | 51 (18-84) | 51 (18-81) |
| Performance status (ECOG) 1 or less, n (%) | 103 (95) | 106 (98) |
| Median spleen, cm (range)* | 10 (0-38) | 10 (0-31) |
| Median Hb, g/L (range) | 107 (68-145) | 112 (53-155) |
| Median platelet count, × 109/L (range) | 520 (130-2586) | 480 (80-4553) |
| Median WBC count, × 109/L (range) | 148 (14-500) | 160 (19-478) |
| Median blood myeloblasts, % (range) | 5 (0-11) | 5 (0-13) |
| Median blood eosinophils, % (range) | 3 (0-12) | 2 (0-17) |
| Median blood basophils, % (range) | 4 (0-19) | 3 (0-15) |
| Additional chromosome abnormalities, no. (%) | 3 (3) | 5 (5) |
| Median Sokal score (range) | 1.57 (1.22-7.61) | 1.57 (1.21-8.25) |
| High risk by Hasford score, no. (%) | 47 (43) | 43 (40) |
No difference was significant. Fifty-eight percent of the patients in the 800-mg arm and 55% of the patients in the 400-mg arm had a short course of treatment with hydroxyurea.
Maximum distance from costal margin, by manual evaluation.