Table 1

Combination indices for BAG956 synergy studies

Cell lines (treatments)ED50ED75ED90
Ba/F3.p210 (BAG956 + nilotinib) 1.26625 0.96529 0.80264 
Ba/F3.p210 (BAG956 + imatinib) 0.94479 0.50129 0.28934 
Ba/F3.p210 (BAG956 + rapamycin) 0.42898 0.17615 0.08467 
Ba/F3-T315I (BAG956 + rapamycin) 0.02524 0.05844 0.18044 
Ba/F3-F317L (BAG956 + rapamycin) 0.07848 0.08503 0.26646 
Ba/F3-M351T (BAG956 + rapamycin) 0.05999 0.13925 0.36657 
Ba/F3-FLT3-ITD (BAG956 + PKC412) 1.04707 0.74138 0.58245 
Ba/F3-FLT3-ITD (BAG956 + rapamycin) 0.60424 0.22723 0.38804 
Ba/F3-N676D (BAG956 + rapamycin) 0.06456 0.21785 0.85130 
Ba/F3-G697R (BAG956 + rapamycin) 0.17485 0.13877 0.43206 
Cell lines (treatments)ED50ED75ED90
Ba/F3.p210 (BAG956 + nilotinib) 1.26625 0.96529 0.80264 
Ba/F3.p210 (BAG956 + imatinib) 0.94479 0.50129 0.28934 
Ba/F3.p210 (BAG956 + rapamycin) 0.42898 0.17615 0.08467 
Ba/F3-T315I (BAG956 + rapamycin) 0.02524 0.05844 0.18044 
Ba/F3-F317L (BAG956 + rapamycin) 0.07848 0.08503 0.26646 
Ba/F3-M351T (BAG956 + rapamycin) 0.05999 0.13925 0.36657 
Ba/F3-FLT3-ITD (BAG956 + PKC412) 1.04707 0.74138 0.58245 
Ba/F3-FLT3-ITD (BAG956 + rapamycin) 0.60424 0.22723 0.38804 
Ba/F3-N676D (BAG956 + rapamycin) 0.06456 0.21785 0.85130 
Ba/F3-G697R (BAG956 + rapamycin) 0.17485 0.13877 0.43206 
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