Transcription factor effects on in vivo DC homeostasis
| Transcription factor . | Bone marrow DC progenitor . | Spleen pDC . | Spleen DC CD8a−/+ . | Langerhans cells . | References . |
|---|---|---|---|---|---|
| Stat3−/− | NA | NA | 0.1/0.1 | NA | 63 |
| Gfi-1−/− | 0.2 | 0.5 | 0.5/0.5 | 2 | 65 |
| Stat5−/− | NA | 0.4 | 0.4/0.3 | NA | 66 |
| Ikaros−/− | NA | NA | Absent/0.15 | NA | 122 |
| Ikaros DN−/− | NA | NA | Absent | NA | 122 |
| Ikaros IkL/L | NA | < 0.1 | 0.8/1.1 | NA | 123 |
| Xbp-1−/− | NA | 0.3 | 0.6 | NA | 124 |
| RelB−/− | NA | NA | Absent/1 | 1 | 68 |
| Pu.1−/− | NA | NA | < 0.1/1 | NA | 70,71 |
| Irf-2−/− | NA | NA | 0.25/1 | 0.7 | 73 |
| Irf-4−/− | NA | 0.5-1 | 0.3/1 | NA | 74,75 |
| Irf-8−/− | 1 | 0.1 | 1/0.1 | 0.5 | 76,77 |
| Id2−/− | NA | 1.5 | 1/< 01 | Absent | 78 |
| Runx3−/− | NA | NA | 0.8/2 | Absent | 81 |
| E2-2−/− | NA | < 0.1 | 1/1 | NA | 79 |
| Batf3−/− | NA | 1 | 1/< 0.1 | NA | 80 |
| Transcription factor . | Bone marrow DC progenitor . | Spleen pDC . | Spleen DC CD8a−/+ . | Langerhans cells . | References . |
|---|---|---|---|---|---|
| Stat3−/− | NA | NA | 0.1/0.1 | NA | 63 |
| Gfi-1−/− | 0.2 | 0.5 | 0.5/0.5 | 2 | 65 |
| Stat5−/− | NA | 0.4 | 0.4/0.3 | NA | 66 |
| Ikaros−/− | NA | NA | Absent/0.15 | NA | 122 |
| Ikaros DN−/− | NA | NA | Absent | NA | 122 |
| Ikaros IkL/L | NA | < 0.1 | 0.8/1.1 | NA | 123 |
| Xbp-1−/− | NA | 0.3 | 0.6 | NA | 124 |
| RelB−/− | NA | NA | Absent/1 | 1 | 68 |
| Pu.1−/− | NA | NA | < 0.1/1 | NA | 70,71 |
| Irf-2−/− | NA | NA | 0.25/1 | 0.7 | 73 |
| Irf-4−/− | NA | 0.5-1 | 0.3/1 | NA | 74,75 |
| Irf-8−/− | 1 | 0.1 | 1/0.1 | 0.5 | 76,77 |
| Id2−/− | NA | 1.5 | 1/< 01 | Absent | 78 |
| Runx3−/− | NA | NA | 0.8/2 | Absent | 81 |
| E2-2−/− | NA | < 0.1 | 1/1 | NA | 79 |
| Batf3−/− | NA | 1 | 1/< 0.1 | NA | 80 |
Values are given as approximate fold of wild type.
NA indicates not available.