Toxicity and outcomes
| UPN . | Age . | Status . | EBV . | CMV . | GVHD . | Relapse . | OS . | Day . | COD . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D/R . | PTLD . | D/R . | Reactivation . | Disease . | Acute* . | Chronic . | |||||||
| 001 | 4 | CR2 | +/+ | No | +/+ | No | No | N/A | N/A | No | Dead | +22 | DAH |
| 002 | 26 | PD | UNK/+ | No | −/− | No | No | N/A | N/A | No | Dead | +8 | Sepsis |
| 003 | 6 | CR2 | +/+ | No | −/− | No | No | B | No | D+1440 | Dead | +1758 | T-ALL |
| 004 | 15 | PD | +/+ | No | +/+ | D+64 | No | No | No | No | Dead | +102 | MOF |
| 005 | 7 | PD | +/+ | No | −/− | No | No | C | N/A | No | Dead | +39 | Fungus |
| 006 | 23 | PD | +/+ | No | −/− | No | No | No | N/A | No | Dead | +31 | MOF |
| 007 | 7 | CR2 | +/+ | No | −/+ | No | No | No | No | No | Alive | +3909 | — |
| 008 | 20 | CR3 | +/+ | No | −/− | No | No | No | N/A | No | Dead | +24 | Fungus |
| 009 | 12 | PD | +/+ | No | −/+ | D+32,150†† | No | No | Yes† | No | Alive | +3708 | — |
| 010 | 1.5 | N/A | −/− | No | −/− | No | No | No | No | No | Alive | +3694 | — |
| 011 | 0.5 | PD | +/+ | No | −/− | No | No | B | N/A | D+60 | Dead | +70 | AML |
| 012 | 16 | PD | +/+ | No | −/− | No | No | No | No | No | Alive | +3520 | — |
| 013 | 4 | N/A | +/+ | No | +/− | No | No | No | No | No | Alive | +3394 | — |
| 014 | 19 | PD | +/+ | No | +/− | No | No | No | N/A | No | Dead | +35 | Sepsis |
| 015 | 45 | CR2 | +/+ | No | −/− | No | No | C | No | No | Dead | +176 | UNK |
| 016 | 50 | PD | +/+ | No | −/− | No | No | B | N/A | D+50 | Dead | +149 | AML |
| 017 | 6 | PD | +/+ | No | +/+ | No | No | B | N/A | No | Dead | +38 | VOD |
| 018 | 42 | PD | +/+ | No | +/+ | D+37, +103 | No | D | No | No | Dead | +159 | aGVHD§ |
| 019 | 16 | PD | +/− | No | −/− | No | No | N/A¶ | N/A | D+90 | Dead | +563 | AML |
| 020 | 12 | PD | +/+ | No | −/− | No | No | C | No | No | Alive | +2966 | — |
| 021 | 6 | N/A | +/+ | No | −/+ | D+32 | No | No | No | No | Alive | +2890 | — |
| 022 | 6 | PD | +/− | No | −/− | No | No | No | N/A | No | Dead | +71 | Sepsis |
| 023 | 4 | CR2 | +/+ | No | −/+ | No | No | No | N/A | No | Dead | +31 | MOF |
| 024 | 4 | CR2 | +/+ | No | +/+ | D+44 | No | C | No | No | Alive | +2647 | — |
| Total | 9/21‖, 5/21** | 1/12 | 4/24 | 8/24 | |||||||||
| UPN . | Age . | Status . | EBV . | CMV . | GVHD . | Relapse . | OS . | Day . | COD . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D/R . | PTLD . | D/R . | Reactivation . | Disease . | Acute* . | Chronic . | |||||||
| 001 | 4 | CR2 | +/+ | No | +/+ | No | No | N/A | N/A | No | Dead | +22 | DAH |
| 002 | 26 | PD | UNK/+ | No | −/− | No | No | N/A | N/A | No | Dead | +8 | Sepsis |
| 003 | 6 | CR2 | +/+ | No | −/− | No | No | B | No | D+1440 | Dead | +1758 | T-ALL |
| 004 | 15 | PD | +/+ | No | +/+ | D+64 | No | No | No | No | Dead | +102 | MOF |
| 005 | 7 | PD | +/+ | No | −/− | No | No | C | N/A | No | Dead | +39 | Fungus |
| 006 | 23 | PD | +/+ | No | −/− | No | No | No | N/A | No | Dead | +31 | MOF |
| 007 | 7 | CR2 | +/+ | No | −/+ | No | No | No | No | No | Alive | +3909 | — |
| 008 | 20 | CR3 | +/+ | No | −/− | No | No | No | N/A | No | Dead | +24 | Fungus |
| 009 | 12 | PD | +/+ | No | −/+ | D+32,150†† | No | No | Yes† | No | Alive | +3708 | — |
| 010 | 1.5 | N/A | −/− | No | −/− | No | No | No | No | No | Alive | +3694 | — |
| 011 | 0.5 | PD | +/+ | No | −/− | No | No | B | N/A | D+60 | Dead | +70 | AML |
| 012 | 16 | PD | +/+ | No | −/− | No | No | No | No | No | Alive | +3520 | — |
| 013 | 4 | N/A | +/+ | No | +/− | No | No | No | No | No | Alive | +3394 | — |
| 014 | 19 | PD | +/+ | No | +/− | No | No | No | N/A | No | Dead | +35 | Sepsis |
| 015 | 45 | CR2 | +/+ | No | −/− | No | No | C | No | No | Dead | +176 | UNK |
| 016 | 50 | PD | +/+ | No | −/− | No | No | B | N/A | D+50 | Dead | +149 | AML |
| 017 | 6 | PD | +/+ | No | +/+ | No | No | B | N/A | No | Dead | +38 | VOD |
| 018 | 42 | PD | +/+ | No | +/+ | D+37, +103 | No | D | No | No | Dead | +159 | aGVHD§ |
| 019 | 16 | PD | +/− | No | −/− | No | No | N/A¶ | N/A | D+90 | Dead | +563 | AML |
| 020 | 12 | PD | +/+ | No | −/− | No | No | C | No | No | Alive | +2966 | — |
| 021 | 6 | N/A | +/+ | No | −/+ | D+32 | No | No | No | No | Alive | +2890 | — |
| 022 | 6 | PD | +/− | No | −/− | No | No | No | N/A | No | Dead | +71 | Sepsis |
| 023 | 4 | CR2 | +/+ | No | −/+ | No | No | No | N/A | No | Dead | +31 | MOF |
| 024 | 4 | CR2 | +/+ | No | +/+ | D+44 | No | C | No | No | Alive | +2647 | — |
| Total | 9/21‖, 5/21** | 1/12 | 4/24 | 8/24 | |||||||||
CMV risk summary: 13/24 were low-risk (donor and recipient CMV-seronegative); 11/24 were high-risk (donor, recipient, or both CMV-seropositive).
D/R indicates donor/recipient serostatus; EBV, Epstein-Barr virus; PTLD, posttransplant lymphoproliferative disorder; CMV, cytomegalovirus; TRM, treatment-related mortality; GVHD, graft-versus-host disease; OS, overall survival; COD, cause of death; DAH, diffuse alveolar hemorrhage; VOD, veno-occlusive disease; MOF, multiorgan failure; and —, not applicable. Other abbreviations as in Table 1.
IBMTR Severity Index Criteria.
cGVHD resolving after 6 months immunosuppression.
Diagnosed on histologic appearance of GI biopsies postmortem.
UPN018 died of probable fungal infection (radiologic evidence) while on immunosuppression for aGVHD.
UPN019 failed to engraft despite two infusions on alloanergized BMT.
IBMTR grades B-D.
IBMTR grades C-D.
UPN 009 had a history of prior CMV disease and was given extended anti-CMV treatment.