Table 1

Pathologic GVHD

WT Allo-HCT
GKO Allo-HCT
Spc + BMCSpcSpc + BMCSpc
DOD 16 48 13 14 14 21 21 26 17 17 17 
Liver − ++ ++ ++ +++ 
Lung − − − − − ++ +++ +++ +++ ++ 
WT Allo-HCT
GKO Allo-HCT
Spc + BMCSpcSpc + BMCSpc
DOD 16 48 13 14 14 21 21 26 17 17 17 
Liver − ++ ++ ++ +++ 
Lung − − − − − ++ +++ +++ +++ ++ 

Recipient mice received 6 Gy TBI followed by administration of 3 × 107 splenocytes alone (Spc) or along with 107 bone marrow cells (Spc + BMC) from WT or GKO B6 donors. Carcasses were saved in 10% formalin after death. Tissue sections were examined blindly by a pathologist and graded as follows: − indicates no detectable lesions; +, minimal lesions; ++, moderate lesions; +++, severe lesions.

DOD indicates date of death (days after HCT).

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