Hematologic values by genotype in adult mice
| Genotype . | RBC, × 1012/L . | Hgb, g/L . | Hct, % . | MCV, fL . | MCH, pg . | MCHC, g/L . | RDW, % . | HDW, g/L . | Retic, % . | Spleen weight, % BW . |
|---|---|---|---|---|---|---|---|---|---|---|
| Male | ||||||||||
| Add1+/+ (18) | 10.1 ± 0.5 | 161.9 ± 10.2 | 47.2 ± 2.4 | 47.0 ± 2.7 | 16.1 ± 0.8 | 343.5 ± 21.5 | 13.0 ± 0.7 | 19.2 ± 1.4 | 2.8 ± 0.6 | 0.32 ± 0.05 |
| Add1−1 (7) | 10.1 ± 0.7 | 160.6 ± 6.1 | 46.5 ± 2.3 | 46.3 ± 1.8 | 15.9 ± 0.8 | 344.8 ± 9.4 | 12.3 ± 0.4 | 17.8 ± 1.2 | 3.2 ± 0.9 | 0.36 ± 0.08 |
| Add1−1 (15) | 10.3 ± 1.0 | 155.7 ± 8.7 | 42.6 ± 2.7‡ | 41.7 ± 3.2‡ | 15.2 ± 1.0* | 365.5 ± 19.0† | 16.0 ± 1.6‡ | 27.6 ± 4.3‡ | 5.5 ± 2.3‡ | 0.36 ± 0.11 |
| Female | ||||||||||
| Add1+/+ (23) | 9.5 ± 0.9 | 156.3 ± 16.4 | 44.3 ± 4.0 | 45.7 ± 3.0 | 16.4 ± 0.5 | 360.3 ± 19.0 | 12.7 ± 0.9 | 19.9 ± 1.4 | 2.6 ± 0.9 | 0.43 ± 0.09 |
| Add1−1 (17) | 9.9 ± 0.0.7 | 160.1 ± 12.2 | 45.9 ± 3.2 | 46.2 ± 1.6 | 16.1 ± 0.8 | 348.9 ± 18.0 | 12.6 ± 0.4 | 18.7 ± 0.9 | 3.0 ± 1.0 | 0.44 ± 0.07 |
| Add1−1 (10) | 10.7 ± 0.9† | 161.5 ± 10.3 | 45.0 ± 2.6 | 42.2 ± 3.3† | 15.1 ± 1.4‡ | 365.7 ± 21.7 | 14.7 ± 1.9‡ | 26.8 ± 5.3‡ | 4.0 ± 1.2† | 0.46 ± 0.16 |
| Genotype . | RBC, × 1012/L . | Hgb, g/L . | Hct, % . | MCV, fL . | MCH, pg . | MCHC, g/L . | RDW, % . | HDW, g/L . | Retic, % . | Spleen weight, % BW . |
|---|---|---|---|---|---|---|---|---|---|---|
| Male | ||||||||||
| Add1+/+ (18) | 10.1 ± 0.5 | 161.9 ± 10.2 | 47.2 ± 2.4 | 47.0 ± 2.7 | 16.1 ± 0.8 | 343.5 ± 21.5 | 13.0 ± 0.7 | 19.2 ± 1.4 | 2.8 ± 0.6 | 0.32 ± 0.05 |
| Add1−1 (7) | 10.1 ± 0.7 | 160.6 ± 6.1 | 46.5 ± 2.3 | 46.3 ± 1.8 | 15.9 ± 0.8 | 344.8 ± 9.4 | 12.3 ± 0.4 | 17.8 ± 1.2 | 3.2 ± 0.9 | 0.36 ± 0.08 |
| Add1−1 (15) | 10.3 ± 1.0 | 155.7 ± 8.7 | 42.6 ± 2.7‡ | 41.7 ± 3.2‡ | 15.2 ± 1.0* | 365.5 ± 19.0† | 16.0 ± 1.6‡ | 27.6 ± 4.3‡ | 5.5 ± 2.3‡ | 0.36 ± 0.11 |
| Female | ||||||||||
| Add1+/+ (23) | 9.5 ± 0.9 | 156.3 ± 16.4 | 44.3 ± 4.0 | 45.7 ± 3.0 | 16.4 ± 0.5 | 360.3 ± 19.0 | 12.7 ± 0.9 | 19.9 ± 1.4 | 2.6 ± 0.9 | 0.43 ± 0.09 |
| Add1−1 (17) | 9.9 ± 0.0.7 | 160.1 ± 12.2 | 45.9 ± 3.2 | 46.2 ± 1.6 | 16.1 ± 0.8 | 348.9 ± 18.0 | 12.6 ± 0.4 | 18.7 ± 0.9 | 3.0 ± 1.0 | 0.44 ± 0.07 |
| Add1−1 (10) | 10.7 ± 0.9† | 161.5 ± 10.3 | 45.0 ± 2.6 | 42.2 ± 3.3† | 15.1 ± 1.4‡ | 365.7 ± 21.7 | 14.7 ± 1.9‡ | 26.8 ± 5.3‡ | 4.0 ± 1.2† | 0.46 ± 0.16 |
All mice were 4 or more weeks of age. All mice with overt signs of hydrocephalus or that developed hydrocephalus subsequent to obtaining complete blood counts were excluded. Number in parentheses is sample n. All values X plus or minus SD. Data shown exclude all mice showing any signs of hydrocephalus.
RBC indicates red blood cell count; Hgb, hemoglobin; Hct, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin content; RDW, red cell distribution width; HDW, hemoglobin distribution width; Retic, reticulocytes; and BW, body weight.
P < .05,
P < .01,
P < .001 versus sex-matched control (+/+) mice.