Table 1 TNF (−308A) polymorphism is... | American Society of Hematology

Table 1

TNF (−308A) polymorphism is associated with reduced immune responsiveness, as measured by recipient to donor direction mixed lymphocyte culture (MLC), and is possibly also associated with reduced lymphocyte mitogen responsiveness (PHA)

SNP	MLC		PHA
SNP	SI difference, 95% CI*	P†	SI difference, 95% CI*	P‡
TNF (−308A)	−4.2 (−8.2 to −0.1)	0.04	−8.1 (−17.9 to 1.6)	.10
IL 10 (−1082G)	1.2 (−3.5 to 6.0)	0.60	−3.5 (−11.5 to 4.5)	.38
TGFB1 (+915C)	−1.1 (−6.3 to 4.1)	0.53	−3.1 (−11.9 to 5.6)	.47
IFNG (+874T)	1.4 (−3.2 to 6.1)	0.68	−0.1 (−11.6 to 11.8)	.98

SNP	MLC		PHA
SNP	SI difference, 95% CI*	P†	SI difference, 95% CI*	P‡
TNF (−308A)	−4.2 (−8.2 to −0.1)	0.04	−8.1 (−17.9 to 1.6)	.10
IL 10 (−1082G)	1.2 (−3.5 to 6.0)	0.60	−3.5 (−11.5 to 4.5)	.38
TGFB1 (+915C)	−1.1 (−6.3 to 4.1)	0.53	−3.1 (−11.9 to 5.6)	.47
IFNG (+874T)	1.4 (−3.2 to 6.1)	0.68	−0.1 (−11.6 to 11.8)	.98

Stimulation index of SNP, adjusted for Injury Severity Score.

†

P value calculated using linear regression, with clustering on recipients.

‡

P value calculated using linear regression.

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