Results of multivariate Cox regression analyses of OS and EFS in the test cohort
| Variable . | Overall survival (n = 78)* . | Event-free survival (n = 77)† . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Age‡ | 1.43 (1.10-1.87) | .009 | 1.34 (1.07-1.69) | .011 |
| NPM1 mutation | 0.54 (0.29-1.02) | .06 | 0.41 (0.23-0.73) | .002 |
| FLT3 ITD§ | ||||
| Low FLT3 ITD/wt ratio | 1.38 (0.64-2.97) | .41 | 1.12 (0.55-2.27) | .74 |
| High FLT3 ITD/wt ratio | 1.26 (0.42-3.82) | .61 | 1.52 (0.51-4.54) | .45 |
| Microarray-based continuous risk score‖ | 1.64 (1.07-2.54) | .037 | 1.68 (1.07-2.64) | .024 |
| Variable . | Overall survival (n = 78)* . | Event-free survival (n = 77)† . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Age‡ | 1.43 (1.10-1.87) | .009 | 1.34 (1.07-1.69) | .011 |
| NPM1 mutation | 0.54 (0.29-1.02) | .06 | 0.41 (0.23-0.73) | .002 |
| FLT3 ITD§ | ||||
| Low FLT3 ITD/wt ratio | 1.38 (0.64-2.97) | .41 | 1.12 (0.55-2.27) | .74 |
| High FLT3 ITD/wt ratio | 1.26 (0.42-3.82) | .61 | 1.52 (0.51-4.54) | .45 |
| Microarray-based continuous risk score‖ | 1.64 (1.07-2.54) | .037 | 1.68 (1.07-2.64) | .024 |
One patient was not included because of missing data on FLT3 ITD/wt allelic ratio.
Data on EFS were available for 77 of the 79 patients in the test dataset.
The hazard ratio is given for an age difference of 10 years.
Hazard ratios are for the comparison with patients without detectable FLT3 ITD (ie, a FLT3 ITD/wt allelic ratio of 0).
The hazard ratio is given for a change of the score equal to its interquartile range.